CD70 binds CD27

Stable Identifier
R-HSA-5669024
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The CD70 antigen (CD70) is a cytokine that is found on the surface of activated but not resting T and B lymphocytes (Bowman et al. 1994). CD70 can bind to the CD27 antigen receptor (CD27), a dimeric membrane glycoprotein belonging to the tumor necrosis factor receptor family and found on the surface of most T lymphocytes (Camerini et al. 1991). This complex is thought to influence T-, B- and NK-cell functions (Salzer et al. 2013). Defects in CD27 can cause lymphoproliferative syndrome 2 (LPFS2), an autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction (van Montfrans et al. 2012, Salzer et al. 2013).

Literature References
PubMed ID Title Journal Year
22197273 CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia

van Montfrans, JM, Hoepelman, AI, Otto, S, van Gijn, M, van de Corput, L, de Weger, RA, Monaco-Shawver, L, Banerjee, PP, Sanders, EA, Jol-van der Zijde, CM, Betts, MR, Orange, JS, Bloem, AC, Tesselaar, K

J. Allergy Clin. Immunol. 2012
22801960 Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27

Salzer, E, Daschkey, S, Choo, S, Gombert, M, Santos-Valente, E, Ginzel, S, Schwendinger, M, Haas, OA, Fritsch, G, Pickl, WF, Förster-Waldl, E, Borkhardt, A, Boztug, K, Bienemann, K, Seidel, MG

Haematologica 2013
1655907 The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family

Camerini, D, Walz, G, Loenen, WA, Borst, J, Seed, B

J. Immunol. 1991
8120384 The cloning of CD70 and its identification as the ligand for CD27

Bowman, MR, Crimmins, MA, Yetz-Aldape, J, Kriz, R, Kelleher, K, Herrmann, S

J. Immunol. 1994
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