Reactome | TNFs bind their physiological receptors

TNFs bind their physiological receptors

Stable Identifier

R-HSA-5669034

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Summation

Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. These members are implicated in various acquired or genetic human diseases, ranging from septic shock to autoimmune disorders, allograft rejection and cancer (So et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16443545	Tumor necrosis factor/tumor necrosis factor receptor family members that positively regulate immunity	Int. J. Hematol.	2006

Participants

Events

Participant Of

hasEvent

TNFR2 non-canonical NF-kB pathway

Orthologous Events

TNFs bind their physiological receptors (Bos taurus)

TNFs bind their physiological receptors (Canis familiaris)

TNFs bind their physiological receptors (Danio rerio)

TNFs bind their physiological receptors (Gallus gallus)

TNFs bind their physiological receptors (Mus musculus)

TNFs bind their physiological receptors (Rattus norvegicus)

TNFs bind their physiological receptors (Sus scrofa)

TNFs bind their physiological receptors (Taeniopygia guttata)

TNFs bind their physiological receptors (Xenopus tropicalis)