Reactome: A Curated Pathway Database

TNFs bind their physiological receptors

Stable Identifier
R-HSA-5669034
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Members of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. These members are implicated in various acquired or genetic human diseases, ranging from septic shock to autoimmune disorders, allograft rejection and cancer (So et al. 2006).

Literature References
Participants
Participant Of
Orthologous Events