LTA trimer binds TNFRSF1A,1B,14

Stable Identifier
R-HSA-5669097
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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LTA trimer binds TNFRSF1A,1B,14
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Lymphotoxin-alpha (LTA) is a cytokine produced by lymphocytes that plays an important role in the inflammatory and immunologic response. LTA is a product of stimulated T cells and can help elicit cytotoxic effects on cancer cells. In its homotrimeric form, LTA binds the tumor necrosis factor receptor superfamily members TNFRSF1A, 1B and 14 (Aggarwal 2003).

Literature References
PubMed ID Title Journal Year
12949498 Signalling pathways of the TNF superfamily: a double-edged sword

Aggarwal, BB

Nat. Rev. Immunol. 2003
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Orthologous Events
LTA trimer binds TNFRSF1A,1B,14 (Bos taurus)
LTA trimer binds TNFRSF1A,1B,14 (Canis familiaris)
LTA trimer binds TNFRSF1A,1B,14 (Danio rerio)
LTA trimer binds TNFRSF1A,1B,14 (Mus musculus)
LTA trimer binds TNFRSF1A,1B,14 (Rattus norvegicus)
LTA trimer binds TNFRSF1A,1B,14 (Sus scrofa)
LTA trimer binds TNFRSF1A,1B,14 (Xenopus tropicalis)
Authored
Jassal, B  (2015-01-30)
Reviewed
Ware, CF  (2015-05-12)
Virgen-Slane, R  (2015-05-12)
Rajput, A  (2015-05-12)
Created
Jassal, B  (2015-01-30)