LTA trimer binds TNFRSF1A,1B,14

Stable Identifier
R-HSA-5669097
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Lymphotoxin-alpha (LTA) is a cytokine produced by lymphocytes that plays an important role in the inflammatory and immunologic response. LTA is a product of stimulated T cells and can help elicit cytotoxic effects on cancer cells. In its homotrimeric form, LTA binds the tumor necrosis factor receptor superfamily members TNFRSF1A, 1B and 14 (Aggarwal 2003).

Literature References
PubMed ID Title Journal Year
12949498 Signalling pathways of the TNF superfamily: a double-edged sword Nat. Rev. Immunol. 2003
Participants
Participant Of
Orthologous Events