FLNA binds PAK1

Stable Identifier
R-HSA-5669240
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FLNA binds PAK1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The CRIB domain of PAK1 binds to the C-terminal part (repeat 23) of filamin A (FLNA). The interaction is enhanced upon PAK1 activation (Vadlamudi et al. 2002).
Literature References
PubMed ID Title Journal Year
12198493 Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

Stossel, TP, Li, F, Kumar, R, Vadlamudi, RK, Nguyen, D, Ohta, Y, Adam, L

Nat. Cell Biol. 2002
Participants
Input
Output
Participates
as an event of
Orthologous Events
FLNA binds PAK1 (Bos taurus)
FLNA binds PAK1 (Caenorhabditis elegans)
FLNA binds PAK1 (Canis familiaris)
FLNA binds PAK1 (Dictyostelium discoideum)
FLNA binds PAK1 (Drosophila melanogaster)
FLNA binds PAK1 (Mus musculus)
FLNA binds PAK1 (Rattus norvegicus)
FLNA binds PAK1 (Sus scrofa)
FLNA binds PAK1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-02-02)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-31)
Cite Us!