AP1G2 binds HGS and CHMP2A

Stable Identifier
R-HSA-5671702
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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AP-1 complex subunit gamma-like 2 (AP1G2) is an 87-kDa protein that is similar to gamma-adaptin (AP1G1), a large chain of the AP1 clathrin-associated adaptor complex, both in primary structure (60% amino acid identity) and domain organisation (Takatsu et al. 1998). AP1G2 can be viewed as a putative endosomal sorting and trafficking adaptor that is specifically required for degradative endocytic trafficking and may help in maintaining homeostasis of the multivesicular body (MVB) protein-sorting pathway. AP1G2 specifically interacts with the core ESCRT subunits hepatocyte growth factor-regulated tyrosine kinase substrate (HGS, aka HRS) and charged multivesicular body protein 2a (CHMP2A aka hVps2-1), involved in MVB processing (Doring et al. 2010).

AP1G2 is also able to bind the large envelope protein (surface protein S) of the hepatitis B virus (HBV), a protein that plays an important role in viral budding (Hartmann-Stuhler & Prange 2001). Disruption of this binding can inhibit virus production (Rost et al. 2006). Thus, AP1G2 may play a role in L-mediated processes of viral biogenesis or pathogenesis.

Literature References
PubMed ID Title Journal Year
20708039 ?2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits

Döring, T, Gotthardt, K, Stieler, J, Prange, R

Biochim. Biophys. Acta 2010
11333915 Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein

Hartmann-Stühler, C, Prange, R

J. Virol. 2001
9733768 Identification and characterization of novel clathrin adaptor-related proteins

Takatsu, H, Sakurai, M, Shin, HW, Murakami, K, Nakayama, K

J. Biol. Chem. 1998
16867982 Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation

Rost, M, Mann, S, Lambert, C, Döring, T, Thomé, N, Prange, R

J. Biol. Chem. 2006
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