Activated CIT phosphorylates MRLCs

Stable Identifier
R-HSA-5671919
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated CIT phosphorylates MRLCs (mysoin regulatory light chains) at threonine T19 and serine S20 (also labeled in the literature as T18 and S19), and can restore stress fibre assembly when ROCKs are inhibited, although ROCKs play the dominant role in stress fiber formation-related phosphorylation of MRLCs. CIT-mediated phosphorylation of MRLCs may be important during cytokinesis. Unlike ROCKs, CIT does not phosphorylate the myosin binding subunit of the myosin phosphatase complex (Yamashiro et al. 2003).

Literature References
PubMed ID Title Journal Year
12802051 Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II

Yamashiro, S, Totsukawa, G, Yamakita, Y, Sasaki, Y, Madaule, P, Ishizaki, T, Narumiya, S, Matsumura, F

Mol. Biol. Cell 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane]
Physical Entity
Activity
This event is regulated
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Created