CIT binds CDKN1B

Stable Identifier
R-HSA-5671972
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The tumor suppressor CDKN1B (p27Kip1) binds CIT (citron kinase) and prevents its association with RHO GTPases. CDKN1B and CIT colocalize at the contractile ring and mid-body of dividing cells and it is thought that CDKN1B controls cytokinesis by regulating CIT activation (Serres et al. 2012).

Literature References
PubMed ID Title Journal Year
22293177 p27(Kip1) controls cytokinesis via the regulation of citron kinase activation

Serres, MP, Kossatz, U, Chi, Y, Roberts, JM, Malek, NP, Besson, A

J. Clin. Invest. 2012
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