Rheb in the mTORC1 complex hydrolyses GTP

Stable Identifier
R-HSA-5672017
Type
Reaction
Species
Homo sapiens
Compartment
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When cellular energy is depleted AMPK is activated and inhibits mTORC1 via phosphorylation of both TSC2 and Raptor (Gwinn et al. 2008). Phosphorylation of TSC2 increases its GAP activity on GTP-bound Rheb, enhancing the intrinsic GTPase activity of Rheb. Rheb converts its bound GTP to GDP which diminishes its stimulation of mTORC1 and thereby decreases mTORC1 kinase activity. AMPK also phosphorylates the mTORC1 component RPTOR (Raptor), which promotes its dissociation from the ULK1 complex. Both effects of AMPK lead to a reduction in S758 phosphorylation on ULK1 (Shang et al. 2011). The S758-unphosphorylated ULK1 is able to associate with, and be activated by, AMPK (Egan et al. 2011).

This event is positively regulated by the phosphorylation of the TSC complex by p-AMPK.

Literature References
PubMed ID Title Journal Year
18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoint

Gwinn, DM, Shackelford, DB, Egan, DF, Mihaylova, MM, Mery, A, Vasquez, DS, Turk, BE, Shaw, RJ

Mol Cell 2008
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hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
GTPase activity of mTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
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