The C-terminal region of KTN1 (kinectin) binds the cargo-binding tail of the kinesin heavy chain KIF5A and enhances microtubule-stimulated ATPase activity of KIF5A. KIF5A is a part of the conventional kinesin complex, kinesin-1. RHO GTPases, KTN1 and kinesin-1 colocalize on endoplasmic reticulum (ER) membranes and ER-derived vesicles and are thought to be involved in organelle/vesicle motility (Ong et al. 2000, Vignal et al. 2001)
Vignal, E, Blangy, A, Martin, M, Gauthier-Rouvière, C, Fort, P
Ong, LL, Lim, AP, Er, CP, Kuznetsov, SA, Yu, H
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