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KSR1 [cytosol]
Stable Identifier
R-HSA-5672587
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1 [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1 [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
BRAP binds KSR1:MARK3 (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1 [cytosol] (Homo sapiens)
KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1 [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
MARK3 phosphorylates KSR1 (Homo sapiens)
KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1 [cytosol] (Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IVT5 KSR1
Gene Names
KSR1, KSR
Chain
chain:1-923
Reference Genes
BioGPS Gene:8844 KSR1
COSMIC (genes):KSR1 KSR1
CTD Gene:8844 KSR1
dbSNP Gene:8844 KSR1
ENSEMBL:ENSG00000141068 KSR1
HGNC:6465 KSR1
KEGG:hsa:8844 KSR1
Monarch:8844 KSR1
NCBI Gene:8844 KSR1
OMIM:601132 KSR1
UCSC:Q8IVT5 KSR1
Reference Transcript
RefSeq:XM_011525429.2 KSR1
RefSeq:XM_017025275.1 KSR1
RefSeq:NM_014238.1 KSR1
RefSeq:XM_017025276.1 KSR1
RefSeq:XM_017025272.1 KSR1
RefSeq:XM_017025271.1 KSR1
RefSeq:XM_017025274.1 KSR1
RefSeq:XM_017025273.1 KSR1
Other Identifiers
11740384_a_at
16832350
1716_at
213767_PM_at
213767_at
213769_PM_at
213769_at
235252_PM_at
235252_at
3005002
3715197
3715198
3715200
3715203
3715211
3715215
3715219
3715220
3715222
3715223
3715226
3715227
3715228
3715229
3715231
3715232
3715234
3715235
3715236
3715237
3715239
3715242
3715243
3715244
3715245
3715246
3715247
3715248
3715249
3715250
3715251
3715252
3715253
3715254
3715257
3715259
3715260
3715261
3715262
3715263
3715264
3715265
3715266
3715267
3715272
3715273
3715275
8005785
80554_s_at
84487_at
8844
92089_at
A_14_P114125
A_23_P207774
A_24_P255483
A_24_P911112
A_32_P66091
GE80370
GE87872
GO:0000165
GO:0003824
GO:0004672
GO:0004674
GO:0005078
GO:0005515
GO:0005524
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006468
GO:0007265
GO:0016020
GO:0016740
GO:0019901
GO:0019933
GO:0031434
GO:0032587
GO:0032991
GO:0042127
GO:0042995
GO:0043226
GO:0043231
GO:0043405
GO:0043410
GO:0046872
GO:0051087
GO:0051879
GO:0060090
GO:0071889
GO:0106310
GO:0140096
HMNXSV003005518
HMNXSV003015816
HMNXSV003023535
Hs.152094.0.A1_3p_at
Hs.152094.0.A2_3p_at
Hs.169061.0.A1_3p_at
ILMN_1754798
PH_hs_0023378
TC17000311.hg
U43586_at
p26022
Participates
as a component of
KSR1:MARK3 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S311,Y602 KSR1 [cytosol]
p-S311,Y602 KSR1 [plasma membrane]
p-S311 KSR1 [cytosol]
p-S311,S406 KSR1 [cytosol]
Inferred To
Ksr1 [cytosol]
(Rattus norvegicus)
Homologues of KSR1 [cytosol]
(Dictyostelium discoideum)
KSR1 [cytosol]
(Bos taurus)
KSR1 [cytosol]
(Caenorhabditis elegans)
KSR1 [cytosol]
(Canis familiaris)
KSR1 [cytosol]
(Dictyostelium discoideum)
KSR1 [cytosol]
(Drosophila melanogaster)
KSR1 [cytosol]
(Mus musculus)
KSR1 [cytosol]
(Plasmodium falciparum)
KSR1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016880765.1
,
XP_016880762.1
,
XP_016880764.1
,
XP_016880763.1
,
XP_011523731.1
,
NP_055053.1
,
XP_016880761.1
,
XP_016880760.1
Guide to Pharmacology - Targets
2051
OpenTargets
ENSG00000141068
ENSEMBL
ENST00000398988
,
ENSP00000381958
IntEnz
2.7.11.1
HPA
ENSG00000141068-KSR1
PRO
Q8IVT5
Pharos - Targets
Q8IVT5
PDB
9AXH
,
5VYK
,
7JUZ
,
7JUX
,
7JUW
,
7JUY
,
7JV0
,
7JV1
HMDB Protein
HMDBP10939
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
p-S218,S222-MAP2K1 [cytosol]
(R-HSA-109837)
MAP2K1 [cytosol]
(R-HSA-59502)
p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-HSA-112339)
p-T286,T292-MAP2K1 [cytosol]
(R-HSA-112374)
p-S,218, S222,T292 MAP2K1 [cytosol]
(R-HSA-5674490)
MAP2K1 F53C [cytosol]
(R-HSA-9652028)
MAP2K1 P124Q [cytosol]
(R-HSA-9652058)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
0.837
11
UniProt:P36507 MAP2K2
12
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
0.798
10
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.745
5
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.643
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.604
4
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.564
5
UniProt:P63151 PPP2R2A
2
PPP2R2A [nucleoplasm]
(R-HSA-1564978)
PPP2R2A [cytosol]
(R-HSA-377253)
0.527
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
2
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