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RAS GEFs [plasma membrane]
Stable Identifier
R-HSA-5672601
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Participants
members
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane]
(Homo sapiens)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]
(Homo sapiens)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
(Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
(Homo sapiens)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol]
(Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane]
(Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane]
(Homo sapiens)
SOS-1 bound to Tie2:Grb2 [plasma membrane]
(Homo sapiens)
p-RASGRP1,3:DAG [plasma membrane]
(Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane]
(Homo sapiens)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane]
(Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
GRB2-1:SOS1:p-Y-SHC [cytosol]
(Homo sapiens)
RAPGEF2 [cytosol]
(Homo sapiens)
RASGEF1A [cytosol]
(Homo sapiens)
RASGRF2 [cytosol]
(Homo sapiens)
RASGRP1 [cytosol]
(Homo sapiens)
RASGRP4 [cytosol]
(Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane]
(Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane]
(Homo sapiens)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane]
(Homo sapiens)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]
(Homo sapiens)
Active FLT3:GRB2:SOS1 [plasma membrane]
(Homo sapiens)
Inferred To
RAS GEFs [plasma membrane]
(Bos taurus)
RAS GEFs [plasma membrane]
(Caenorhabditis elegans)
RAS GEFs [plasma membrane]
(Canis familiaris)
RAS GEFs [plasma membrane]
(Danio rerio)
RAS GEFs [plasma membrane]
(Drosophila melanogaster)
RAS GEFs [plasma membrane]
(Gallus gallus)
RAS GEFs [plasma membrane]
(Mus musculus)
RAS GEFs [plasma membrane]
(Rattus norvegicus)
RAS GEFs [plasma membrane]
(Sus scrofa)
RAS GEFs [plasma membrane]
(Xenopus tropicalis)
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