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About
What is Reactome ?
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Team
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Release Calendar
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Our Logo
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Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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Docs
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p-S311 KSR1 [cytosol]
Stable Identifier
R-HSA-5672652
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
dephosphorylated "receiver" RAF/KSR1 [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
PP2A dephosphorylates KSR1 (Homo sapiens)
p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Phosphorylation of RAF (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
dephosphorylated "receiver" RAF/KSR1 [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
dephosphorylated "receiver" RAF/KSR1 [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
dephosphorylated "receiver" RAF/KSR1 [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
dephosphorylated "receiver" RAF/KSR1 [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
dephosphorylated "receiver" RAF/KSR1 [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
YWHAB dimer dissociates from KSR1:MARK3 (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IVT5 KSR1
Gene Names
KSR1, KSR
Chain
chain:1-923
Reference Genes
BioGPS Gene:8844 KSR1
COSMIC (genes):KSR1 KSR1
CTD Gene:8844 KSR1
dbSNP Gene:8844 KSR1
ENSEMBL:ENSG00000141068 KSR1
ENSEMBL_homo_sapiens_GENE:ENSG00000141068.17 KSR1
HGNC:6465 KSR1
KEGG Gene (Homo sapiens):8844 KSR1
Monarch:8844 KSR1
NCBI Gene:8844 KSR1
OMIM:601132 KSR1
UCSC:Q8IVT5 KSR1
Reference Transcript
RefSeq:NM_014238.1 KSR1
RefSeq:XM_017025272.1 KSR1
RefSeq:XM_017025271.1 KSR1
RefSeq:XM_017025275.1 KSR1
RefSeq:XM_011525429.2 KSR1
RefSeq:XM_017025274.1 KSR1
RefSeq:XM_017025273.1 KSR1
RefSeq:XM_017025276.1 KSR1
Other Identifiers
11740384_a_at
16832350
1716_at
213767_PM_at
213767_at
213769_PM_at
213769_at
235252_PM_at
235252_at
3715200
3715203
3715211
3715219
3715222
3715223
3715232
3715234
3715235
3715237
3715239
3715243
3715244
3715245
3715246
3715248
3715249
3715250
3715252
3715254
3715257
3715260
3715261
3715262
3715263
3715264
3715265
3715266
3715267
3715272
3715273
3715275
8005785
80554_s_at
84487_at
8844
92089_at
A_14_P114125
A_24_P255483
A_24_P911112
A_32_P66091
GE80370
GE87872
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0005078
GO:0005515
GO:0005524
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006468
GO:0007265
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019933
GO:0023052
GO:0032587
GO:0032991
GO:0036211
GO:0042127
GO:0042995
GO:0043226
GO:0043231
GO:0043405
GO:0043410
GO:0046872
GO:0060090
GO:0071889
GO:0106310
GO:0140096
HMNXSV003005518
HMNXSV003015816
HMNXSV003023535
Hs.152094.0.A1_3p_at
Hs.152094.0.A2_3p_at
Hs.169061.0.A1_3p_at
ILMN_1754798
PH_hs_0023378
TC17000311.hg
U43586_at
p26022
Participates
as a component of
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S311,S406 KSR1 [cytosol]
KSR1 [cytosol]
p-S311,Y602 KSR1 [plasma membrane]
p-S311,Y602 KSR1 [cytosol]
Inferred To
phospho-p-S311 KSR1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S311 KSR1 [cytosol]
(Drosophila melanogaster)
phospho-p-S311 KSR1 [cytosol]
(Mus musculus)
phospho-p-S311 KSR1 [cytosol]
(Plasmodium falciparum)
phospho-Ksr1 [cytosol]
(Rattus norvegicus)
phospho-KSR1 [cytosol]
(Bos taurus)
phospho-KSR1 [cytosol]
(Canis familiaris)
phospho-KSR1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 311
Coordinate
311
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_011523731.1
,
XP_016880761.1
,
XP_016880763.1
,
XP_016880764.1
,
XP_016880762.1
,
NP_055053.1
,
XP_016880765.1
,
XP_016880760.1
Guide to Pharmacology - Targets
2051
OpenTargets
ENSG00000141068
IntEnz
2.7.11.1
HPA
ENSG00000141068-KSR1
GeneCards
Q8IVT5
Ensembl
ENSP00000381958
,
ENSG00000141068
,
ENST00000398988
PRO
Q8IVT5
Pharos - Targets
Q8IVT5
HMDB Protein
HMDBP10939
PDB
7JUY
,
5VYK
,
7JV1
,
7JUX
,
7JUZ
,
9AXH
,
7JV0
,
7JUW
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
0.837
11
UniProt:P36507 MAP2K2
12
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
0.798
10
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.745
5
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.643
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.604
4
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.564
5
UniProt:P63151 PPP2R2A
2
PPP2R2A [nucleoplasm]
(R-HSA-1564978)
PPP2R2A [cytosol]
(R-HSA-377253)
0.527
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
2
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