Reactome | p-S311,S406 KSR1 [cytosol]

p-S311,S406 KSR1 [cytosol]

Stable Identifier

R-HSA-5672654

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IVT5 KSR1

Gene Names

KSR1, KSR

Chain

chain:1-923

Reference Genes

BioGPS Gene:8844 KSR1

COSMIC (genes):KSR1 KSR1

CTD Gene:8844 KSR1

dbSNP Gene:8844 KSR1

ENSEMBL:ENSG00000141068 KSR1

ENSEMBL_homo_sapiens_GENE:ENSG00000141068.17 KSR1

HGNC:6465 KSR1

KEGG Gene (Homo sapiens):8844 KSR1

Monarch:8844 KSR1

NCBI Gene:8844 KSR1

OMIM:601132 KSR1

UCSC:Q8IVT5 KSR1

Reference Transcript

Other Identifiers

11740384_a_at

16832350

1716_at

213767_PM_at

213767_at

213769_PM_at

213769_at

235252_PM_at

235252_at

3715200

3715203

3715211

3715219

3715222

3715223

3715232

3715234

3715235

3715237

3715239

3715243

3715244

3715245

3715246

3715248

3715249

3715250

3715252

3715254

3715257

3715260

3715261

3715262

3715263

3715264

3715265

3715266

3715267

3715272

3715273

3715275

8005785

80554_s_at

84487_at

8844

92089_at

A_14_P114125

A_24_P255483

A_24_P911112

A_32_P66091

GE80370

GE87872

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0005078

GO:0005515

GO:0005524

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006468

GO:0007265

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019933

GO:0023052

GO:0032587

GO:0032991

GO:0036211

GO:0042127

GO:0042995

GO:0043226

GO:0043231

GO:0043405

GO:0043410

GO:0046872

GO:0060090

GO:0071889

GO:0106310

GO:0140096

HMNXSV003005518

HMNXSV003015816

HMNXSV003023535

Hs.152094.0.A1_3p_at

Hs.152094.0.A2_3p_at

Hs.169061.0.A1_3p_at

ILMN_1754798

PH_hs_0023378

TC17000311.hg

U43586_at

p26022

Participates

as a component of

p-S311,S406 KSR1:MARK3 [cytosol] (Homo sapiens)

Other forms of this molecule

KSR1 [cytosol]

p-S311 KSR1 [cytosol]

p-S311,Y602 KSR1 [plasma membrane]

p-S311,Y602 KSR1 [cytosol]

Inferred To

Homologues of p-S311,S406 KSR1 [cytosol] (Dictyostelium discoideum)

phospho-p-S311,S406 KSR1 [cytosol] (Caenorhabditis elegans)

phospho-p-S311,S406 KSR1 [cytosol] (Dictyostelium discoideum)

phospho-p-S311,S406 KSR1 [cytosol] (Drosophila melanogaster)

phospho-p-S311,S406 KSR1 [cytosol] (Mus musculus)

phospho-p-S311,S406 KSR1 [cytosol] (Plasmodium falciparum)

phospho-Ksr1 [cytosol] (Rattus norvegicus)

phospho-KSR1 [cytosol] (Bos taurus)

phospho-KSR1 [cytosol] (Canis familiaris)

phospho-KSR1 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 311

Coordinate

311

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 406

Coordinate

406

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_011523731.1, XP_016880761.1, XP_016880763.1, XP_016880764.1, XP_016880762.1, NP_055053.1, XP_016880765.1, XP_016880760.1

Guide to Pharmacology - Targets

2051

OpenTargets

ENSG00000141068

IntEnz

2.7.11.1

HPA

ENSG00000141068-KSR1

GeneCards

Q8IVT5

Ensembl

ENSP00000381958, ENSG00000141068, ENST00000398988

PRO

Q8IVT5

Pharos - Targets

Q8IVT5

HMDB Protein

HMDBP10939

PDB

7JUY, 5VYK, 7JV1, 7JUX, 7JUZ, 9AXH, 7JV0, 7JUW

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.837	11
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.798	10
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.745	5
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.643	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.604	4
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.564	5
UniProt:P63151 PPP2R2A	2	PPP2R2A [nucleoplasm] (R-HSA-1564978) PPP2R2A [cytosol] (R-HSA-377253)	0.527	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	2

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