p-S445,T599,S602,S729 BRAF [cytosol]

Stable Identifier
R-HSA-5672676
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
BRAF, B-RAF
Icon
p-S445,T599,S602,S729 BRAF [cytosol] icon
p-S445,T599,S602,S729 BRAF [cytosol] icon
Locations in the PathwayBrowser
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External Reference Information
External Reference
UniProt:P15056 BRAF
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:1, chain:2-766
Reference Genes
BioGPS Gene:673 BRAF
COSMIC (genes):BRAF BRAF
CTD Gene:673 BRAF
dbSNP Gene:673 BRAF
ENSEMBL:ENSG00000157764 BRAF
HGNC:1097 BRAF
KEGG Gene (Homo sapiens):673 BRAF
Monarch:673 BRAF
NCBI Gene:673 BRAF
OMIM:164757 BRAF
UCSC:P15056 BRAF
Reference Transcript
Other Identifiers
11732491_s_at
1654_at
17063631
206044_s_at
3076364
3076365
3076366
3076367
3076368
3076370
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076386
3076388
3076392
3076393
3076396
3076399
3076414
3076416
3076439
3076440
3076441
3076442
3982166
3982173
40306_at
673
8143417
86199_r_at
A_23_P42935
GE58163
GE766137
GO:0000165
GO:0000166
GO:0000186
GO:0003674
GO:0003824
GO:0004672
GO:0004674
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007165
GO:0007173
GO:0008150
GO:0008152
GO:0008219
GO:0009887
GO:0010628
GO:0010828
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0033138
GO:0035556
GO:0042802
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0046872
GO:0048856
GO:0055085
GO:0070374
GO:0070413
GO:0071277
GO:0090150
GO:0097110
GO:0106310
GO:0106311
HMNXSV003020754
ILMN_1652472
M95712_at
PH_hs_0027912
TC07001927.hg
g4757867_3p_a_at
Participates
as a member of
as a component of
as a candidate of
Other forms of this molecule
BRAF-MACF1fusion [cytosol]
p-BRAF-MACF1 fusion [cytosol]
BRAF E501G [cytosol]
BRAF D594N [cytosol]
BRAF D638E [cytosol]
BRAF G596R [cytosol]
BRAF D594V [cytosol]
BRAF G596V [cytosol]
BRAF G466E [cytosol]
BRAF D594G [cytosol]
BRAF L505H [cytosol]
BRAF F595L [cytosol]
BRAF L597V [cytosol]
BRAF G464E [cytosol]
BRAF N581D [cytosol]
BRAF E586K [cytosol]
BRAF V600K [cytosol]
BRAF A246P [cytosol]
BRAF G469V [cytosol]
BRAF T244P [cytosol]
BRAF G469R [cytosol]
BRAF L597R [cytosol]
BRAF G469E [cytosol]
BRAF L597Q [cytosol]
BRAF G466A [cytosol]
BRAF G466V [cytosol]
BRAF N581S [cytosol]
BRAF G464V [cytosol]
p-BRAF L597V [plasma membrane]
p-BRAF L505H [plasma membrane]
p-BRAF G464E [plasma membrane]
p-BRAF F595L [plasma membrane]
p-BRAF A246P [plasma membrane]
p-BRAF E586K [plasma membrane]
p-BRAF N581D [plasma membrane]
p-BRAF V600K [plasma membrane]
p-BRAF G464V [plasma membrane]
p-BRAF T244P [plasma membrane]
p-BRAF G469E [plasma membrane]
p-BRAF G466V [plasma membrane]
p-BRAF G469V [plasma membrane]
p-BRAF G466A [plasma membrane]
p-BRAF L597Q [plasma membrane]
p-BRAF L597R [plasma membrane]
p-BRAF N581S [plasma membrane]
p-BRAF G469R [plasma membrane]
BRAF 599dupT [cytosol]
BRAF G534R [cytosol]
BRAF S467A [cytosol]
BRAF K601N [cytosol]
BRAF G469A [cytosol]
BRAF L485F [cytosol]
BRAF Q257R [cytosol]
BRAF K499E [cytosol]
BRAF V600E [cytosol]
BRAF K601E [cytosol]
BRAF V600E V169_M438del [cytosol]
BRAF V600E V47_D380del [cytosol]
BRAF V600E V47_M438del [cytosol]
V600E BRAF V169_D380del [cytosol]
p-S445,S729-BRAF [plasma membrane]
p-S,T-BRAF [cytosol]
BRAF [cytosol]
p-S365,S445,S729 BRAF [cytosol]
hyperphosphorylated BRAF [plasma membrane]
p-S445,T599,S602,S729 BRAF [plasma membrane]
p-S445,S729-BRAF [cytosol]
Inferred To
phospho-Braf [cytosol] (Mus musculus)
phospho-Braf [cytosol] (Rattus norvegicus)
phospho-BRAF [cytosol] (Bos taurus)
phospho-BRAF [cytosol] (Canis familiaris)
phospho-BRAF [cytosol] (Gallus gallus)
phospho-BRAF [cytosol] (Sus scrofa)
phospho-Raf [cytosol] (Drosophila melanogaster)
phospho-lin-45 [cytosol] (Caenorhabditis elegans)
phospho-drkD [cytosol] (Dictyostelium discoideum)
phospho-braf [cytosol] (Danio rerio)
Modified Residues
Name
O-phospho-L-serine at 445
Coordinate
445
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
GeneCards
HPA
Ensembl
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (25)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q02750 MAP2K1  27 0.977 60
 UniProt:P04049 RAF1  54 0.959 57
 UniProt:P15056 BRAF  68 0.9 13
 UniProt:P63104 YWHAZ  2 0.899 10
 UniProt:P31946 YWHAB  1 0.818 7
 UniProt:P61981 YWHAG  1 0.813 7
 UniProt:P27348 YWHAQ  1 0.813 7
 UniProt:P36507 MAP2K2  12 0.802 9
 UniProt:P01112 HRAS  23 0.783 5
 UniProt:P10398 ARAF  4 0.774 6
 UniProt:P08238 HSP90AB1  6 0.669 4
 UniProt:Q04917 YWHAH  1 0.643 6
 UniProt:P62258 YWHAE  1 0.643 4
 UniProt:Q13233 MAP3K1  2 0.609 2
 UniProt:P01111 NRAS  25 0.591 3
 UniProt:Q02156 PRKCE  2 0.589 3
 UniProt:P31947 SFN  1 0.564 3
 UniProt:P46940 IQGAP1  3 0.544 4
 UniProt:Q16543 CDC37  1 0.527 3
 UniProt:P38646 HSPA9  6 0.527 2
 UniProt:Q8N122 RPTOR  3 0.527 2
 UniProt:P11021 HSPA5  6 0.527 3
 UniProt:P11142 HSPA8  10 0.527 2
 UniProt:Q61097  5 0.499 3
 UniProt:Q99N57  10 0.499 3
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