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What is Reactome ?
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Our Logo
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Privacy Notice
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Table of Contents
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p-S445,T599,S602,S729 BRAF [cytosol]
Stable Identifier
R-HSA-5672676
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
BRAF, B-RAF
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by BRAF and RAF fusions (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Phosphorylation of RAF1 mutants (Homo sapiens)
p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PEBP1 binds activated RAF1 (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Phosphorylation of RAF (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15056 BRAF
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:1, chain:2-766
Reference Genes
BioGPS Gene:673 BRAF
COSMIC (genes):BRAF BRAF
CTD Gene:673 BRAF
dbSNP Gene:673 BRAF
ENSEMBL:ENSG00000157764 BRAF
HGNC:1097 BRAF
KEGG Gene (Homo sapiens):673 BRAF
Monarch:673 BRAF
NCBI Gene:673 BRAF
OMIM:164757 BRAF
UCSC:P15056 BRAF
Reference Transcript
RefSeq:NM_004333.4 BRAF
Other Identifiers
11732491_s_at
1654_at
17063631
206044_s_at
3076364
3076365
3076366
3076367
3076368
3076370
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076386
3076388
3076392
3076393
3076396
3076399
3076414
3076416
3076439
3076440
3076441
3076442
3982166
3982173
40306_at
673
8143417
86199_r_at
A_23_P42935
GE58163
GE766137
GO:0000165
GO:0000166
GO:0000186
GO:0003674
GO:0003824
GO:0004672
GO:0004674
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007165
GO:0007173
GO:0008150
GO:0008152
GO:0008219
GO:0009887
GO:0010628
GO:0010828
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0033138
GO:0035556
GO:0042802
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0046872
GO:0048856
GO:0055085
GO:0070374
GO:0070413
GO:0071277
GO:0090150
GO:0097110
ILMN_1652472
M95712_at
PH_hs_0027912
TC07001927.hg
g4757867_3p_a_at
Participant Of
hasMember
activated RAF monomer [cytosol]
hasCandidate
'activator' RAFs [cytosol]
hasComponent
p-S445,T599,T602,S729 B-Raf complex [cytosol]
Other forms of this molecule
p-S,T-BRAF [cytosol]
BRAF-MACF1fusion [cytosol]
p-BRAF-MACF1 fusion [cytosol]
BRAF [cytosol]
BRAF E501G [cytosol]
BRAF D594N [cytosol]
BRAF D638E [cytosol]
BRAF G596R [cytosol]
BRAF D594V [cytosol]
BRAF G596V [cytosol]
BRAF G466E [cytosol]
BRAF D594G [cytosol]
BRAF L505H [cytosol]
BRAF F595L [cytosol]
BRAF L597V [cytosol]
BRAF G464E [cytosol]
BRAF N581D [cytosol]
BRAF E586K [cytosol]
BRAF V600K [cytosol]
BRAF A246P [cytosol]
BRAF G469V [cytosol]
BRAF T244P [cytosol]
BRAF G469R [cytosol]
BRAF L597R [cytosol]
BRAF G469E [cytosol]
BRAF L597Q [cytosol]
BRAF G466A [cytosol]
BRAF G466V [cytosol]
BRAF N581S [cytosol]
BRAF G464V [cytosol]
p-BRAF L597V [plasma membrane]
p-BRAF L505H [plasma membrane]
p-BRAF G464E [plasma membrane]
p-BRAF F595L [plasma membrane]
p-BRAF A246P [plasma membrane]
p-BRAF E586K [plasma membrane]
p-BRAF N581D [plasma membrane]
p-BRAF V600K [plasma membrane]
p-BRAF G464V [plasma membrane]
p-BRAF T244P [plasma membrane]
p-BRAF G469E [plasma membrane]
p-BRAF G466V [plasma membrane]
p-BRAF G469V [plasma membrane]
p-BRAF G466A [plasma membrane]
p-BRAF L597Q [plasma membrane]
p-BRAF L597R [plasma membrane]
p-BRAF N581S [plasma membrane]
p-BRAF G469R [plasma membrane]
BRAF 599dupT [cytosol]
BRAF G534R [cytosol]
BRAF S467A [cytosol]
BRAF K601N [cytosol]
BRAF G469A [cytosol]
BRAF L485F [cytosol]
BRAF Q257R [cytosol]
BRAF K499E [cytosol]
BRAF V600E [cytosol]
BRAF K601E [cytosol]
BRAF V600E V169_M438del [cytosol]
BRAF V600E V47_D380del [cytosol]
BRAF V600E V47_M438del [cytosol]
V600E BRAF V169_D380del [cytosol]
p-S445,S729-BRAF [plasma membrane]
hyperphosphorylated BRAF [plasma membrane]
p-S365,S445,S729 BRAF [cytosol]
p-S445,T599,S602,S729 BRAF [plasma membrane]
p-S445,S729-BRAF [cytosol]
Inferred To
phospho-rxfp3 [cytosol] (Xenopus tropicalis)
phospho-Braf [cytosol] (Mus musculus)
phospho-Braf [cytosol] (Rattus norvegicus)
phospho-BRAF [cytosol] (Bos taurus)
phospho-BRAF [cytosol] (Canis familiaris)
phospho-BRAF [cytosol] (Gallus gallus)
phospho-BRAF [cytosol] (Sus scrofa)
phospho-shkB [cytosol] (Dictyostelium discoideum)
phospho-braf [cytosol] (Danio rerio)
Modified Residues
Name
O-phospho-L-serine at 445
Coordinate
445
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_004324.2
ZINC - World Drugs
BRAF_HUMAN
OpenTargets
ENSG00000157764
ZINC - FDA approved
BRAF_HUMAN
ZINC - Substances
BRAF_HUMAN
ZINC target
P15056
ZINC - Biogenic
BRAF_HUMAN
PRO
P15056
PDB
6Q0T
,
5JSM
,
5HIE
,
4DBN
,
4KSQ
,
6UAN
,
5VAL
,
4RZW
,
6UUO
,
4FK3
,
3TV6
,
4H58
,
5JT2
,
5J17
,
3Q4C
,
5VAM
,
5VR3
,
5VYK
,
3TV4
,
5ITA
,
4EHE
,
3NY5
,
5JRQ
,
3II5
,
6Q0J
,
5C9C
,
6B8U
,
3PRF
,
4YHT
,
5J2R
,
5HID
,
2FB8
,
6NSQ
,
3PSB
,
4R5Y
,
6Q0K
,
3Q96
,
4CQE
,
3OG7
,
4MNE
,
4RZV
,
5CSX
,
4MBJ
,
1UWH
,
6CAD
,
2L05
,
5CT7
,
3PPJ
,
4XV1
,
4E26
,
4MNF
,
4PP7
,
4FC0
,
6U2H
,
5HI2
,
4XV2
,
6U2G
,
4G9R
,
3C4C
,
4WO5
,
3PRI
,
6N0P
,
3PSD
,
5J18
,
6PP9
,
4XV3
,
5FD2
,
3SKC
,
4EHG
,
1UWJ
,
5CSW
,
3PPK
,
6N0Q
,
3D4Q
,
4XV9
,
4KSP
,
4JVG
,
3IDP
,
4E4X
,
6NYB
,
4G9C
ZINC - Investigational
BRAF_HUMAN
ZINC - Metabolites
BRAF_HUMAN
HPA
ENSG00000157764-BRAF
GeneCards
P15056
Ensembl
ENSG00000157764
,
ENST00000646891
,
ENSP00000493543
Orphanet
15376
ZINC - Predictions - Purchasable
BRAF_HUMAN
HMDB Protein
HMDBP02597
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q02750 MAP2K1
27
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 E44_E57del [cytosol]
(R-HSA-9652026)
MAP2K1 P124Q [cytosol]
(R-HSA-9652058)
MAP2K1 F53C [cytosol]
(R-HSA-9652028)
p-S,218, S222,T292 MAP2K1 [cytosol]
(R-HSA-5674490)
MAP2K1 [cytosol]
(R-HSA-59502)
p-T286,T292-MAP2K1 [cytosol]
(R-HSA-112374)
p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-HSA-112339)
p-S218,S222-MAP2K1 [cytosol]
(R-HSA-109837)
0.977
60
UniProt:P04049 RAF1
54
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.959
57
UniProt:P15056 BRAF
68
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF [cytosol]
(R-HSA-167224)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
BRAF G469R [cytosol]
(R-HSA-9648621)
BRAF L597R [cytosol]
(R-HSA-9648617)
BRAF G469E [cytosol]
(R-HSA-9648618)
BRAF L597Q [cytosol]
(R-HSA-9648619)
BRAF G466A [cytosol]
(R-HSA-9648613)
BRAF G466V [cytosol]
(R-HSA-9648838)
BRAF N581S [cytosol]
(R-HSA-9648850)
BRAF G464V [cytosol]
(R-HSA-9648611)
p-BRAF L597V [plasma membrane]
(R-HSA-8936647)
p-BRAF L505H [plasma membrane]
(R-HSA-9648862)
p-BRAF G464E [plasma membrane]
(R-HSA-8936645)
p-BRAF F595L [plasma membrane]
(R-HSA-8936641)
p-BRAF A246P [plasma membrane]
(R-HSA-9651188)
p-BRAF E586K [plasma membrane]
(R-HSA-8936639)
p-BRAF N581D [plasma membrane]
(R-HSA-9651191)
p-BRAF V600K [plasma membrane]
(R-HSA-8936651)
p-BRAF G464V [plasma membrane]
(R-HSA-9648633)
p-BRAF T244P [plasma membrane]
(R-HSA-9651194)
p-BRAF G469E [plasma membrane]
(R-HSA-9648634)
p-BRAF G466V [plasma membrane]
(R-HSA-9648859)
p-BRAF G469V [plasma membrane]
(R-HSA-9648628)
p-BRAF G466A [plasma membrane]
(R-HSA-9648629)
p-BRAF L597Q [plasma membrane]
(R-HSA-9648630)
p-BRAF L597R [plasma membrane]
(R-HSA-9648631)
p-BRAF N581S [plasma membrane]
(R-HSA-9648866)
p-BRAF G469R [plasma membrane]
(R-HSA-9648627)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
BRAF G534R [cytosol]
(R-HSA-9651134)
BRAF S467A [cytosol]
(R-HSA-9651161)
BRAF K601N [cytosol]
(R-HSA-9648857)
BRAF G469A [cytosol]
(R-HSA-6802381)
BRAF L485F [cytosol]
(R-HSA-9651147)
BRAF Q257R [cytosol]
(R-HSA-9651157)
BRAF K499E [cytosol]
(R-HSA-9651142)
BRAF V600E [cytosol]
(R-HSA-6802498)
BRAF K601E [cytosol]
(R-HSA-9648833)
BRAF V600E V169_M438del [cytosol]
(R-HSA-6802489)
BRAF V600E V47_D380del [cytosol]
(R-HSA-6802491)
BRAF V600E V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.907
13
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.899
10
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.818
7
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.813
7
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.813
7
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.802
6
UniProt:P36507 MAP2K2
12
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
0.802
9
UniProt:P01112 HRAS
23
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
proHRAS [cytosol]
(R-HSA-9647765)
S-Farn-proHRAS [endoplasmic reticulum membrane]
(R-HSA-9647918)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-HSA-9647912)
0.783
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.669
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
6
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.643
4
UniProt:Q13233 MAP3K1
2
p-T1400,T1412-MAP3K1 [cytosol]
(R-HSA-2685607)
MAP3K1 [cytosol]
(R-HSA-166866)
0.609
2
UniProt:P01111 NRAS
25
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
S-Farn-Me PalmS NRAS [plasma membrane]
(R-HSA-9647910)
S-Farn NRAS [endoplasmic reticulum membrane]
(R-HSA-9647782)
S-Farn-Me NRAS [endoplasmic reticulum membrane]
(R-HSA-9647891)
S-Farn-proNRAS [endoplasmic reticulum membrane]
(R-HSA-9647928)
proNRAS [cytosol]
(R-HSA-9647758)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
NRAS [plasma membrane]
(R-HSA-62725)
0.591
3
UniProt:Q02156 PRKCE
2
p-T566,T710,S729-PRKCE [plasma membrane]
(R-HSA-198260)
PRKCE [cytosol]
(R-HSA-58202)
0.589
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.564
3
UniProt:P46940 IQGAP1
3
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.544
4
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.527
3
UniProt:P38646 HSPA9
6
HSPA9 [cytosol]
(R-HSA-5251993)
HSPA9 [nucleoplasm]
(R-HSA-5252128)
HSPA9 [mitochondrial matrix]
(R-HSA-8878802)
HSPA9(1-679) [mitochondrial intermembrane space]
(R-HSA-1267968)
HSPA9 [mitochondrial inner membrane]
(R-HSA-1252206)
HSPA9(1-679) [cytosol]
(R-HSA-1267964)
0.527
2
UniProt:Q8N122 RPTOR
3
RPTOR [cytosol]
(R-HSA-3006727)
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
RPTOR [nucleoplasm]
(R-HSA-5083664)
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.527
2
UniProt:P11021 HSPA5
6
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.527
3
UniProt:Q61097
5
Ksr1 [cytosol]
(R-MMU-5672587)
phospho-Ksr1 [cytosol]
(R-MMU-5672654)
phospho-Ksr1 [cytosol]
(R-MMU-5672652)
phospho-Ksr1 [plasma membrane]
(R-MMU-5672659)
phospho-Ksr1 [cytosol]
(R-MMU-5672656)
0.499
3
UniProt:Q99N57
10
phospho-Raf1 [plasma membrane]
(R-MMU-5672665)
phospho-Raf1 [cytosol]
(R-MMU-5672664)
phospho-Raf1 [cytosol]
(R-MMU-206028)
phospho-Raf1 [cytosol]
(R-MMU-109786)
phospho-Raf1 [plasma membrane]
(R-MMU-5675420)
phospho-Raf1 [plasma membrane]
(R-MMU-206222)
phospho-Raf1 [plasma membrane]
(R-MMU-5675193)
phospho-Raf1 [cytosol]
(R-MMU-5624469)
phospho-Raf1 [cytosol]
(R-MMU-5624465)
Raf1 [cytosol]
(R-MMU-167205)
0.499
3
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![p-S445,T599,S602,S729 BRAF [cytosol] icon](/icon/R-ICO-012447.svg){kind=icon}
