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About
What is Reactome ?
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Table of Contents
DOIs
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p-S445,T599,S602,S729 BRAF [cytosol]
Stable Identifier
R-HSA-5672676
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
BRAF, B-RAF
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by BRAF and RAF fusions (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PEBP1 binds activated RAF1 (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Phosphorylation of RAF (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
activated RAF homo/heterodimer [cytosol] (Homo sapiens)
activated RAF monomer [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PEBP1 binds activated RAF1 (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Phosphorylation of RAF (Homo sapiens)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
'activator' RAFs [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
Dissociation of phosphorylated MAP2Ks and MAPKs (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Homo sapiens)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Homo sapiens)
p-S445,T599,S602,S729 BRAF [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15056 BRAF
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:1, chain:2-766
Reference Genes
BioGPS Gene:673 BRAF
COSMIC (genes):BRAF BRAF
CTD Gene:673 BRAF
dbSNP Gene:673 BRAF
ENSEMBL:ENSG00000157764 BRAF
HGNC:1097 BRAF
KEGG Gene (Homo sapiens):673 BRAF
Monarch:673 BRAF
NCBI Gene:673 BRAF
OMIM:164757 BRAF
UCSC:P15056 BRAF
Reference Transcript
RefSeq:NM_004333.4 BRAF
Other Identifiers
11732491_s_at
1654_at
17063631
1UWH
1UWJ
206044_s_at
2FB8
2L05
3076364
3076365
3076366
3076367
3076368
3076370
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076386
3076388
3076392
3076393
3076396
3076399
3076414
3076416
3076439
3076440
3076441
3076442
3982166
3982173
3C4C
3D4Q
3IDP
3II5
3NY5
3OG7
3PPJ
3PPK
3PRF
3PRI
3PSB
3PSD
3Q4C
3Q96
3SKC
3TV4
3TV6
40306_at
4CQE
4DBN
4E26
4E4X
4EHE
4EHG
4FC0
4FK3
4G9C
4G9R
4H58
4JVG
4KSP
4KSQ
4MBJ
4MNE
4MNF
4PP7
4R5Y
4RZV
4RZW
4WO5
4XV1
4XV2
4XV3
4XV9
4YHT
5C9C
5CSW
5CSX
5CT7
5FD2
5HI2
5HID
5HIE
5ITA
5J17
5J18
5J2R
5JRQ
5JSM
5JT2
5VAL
5VAM
5VR3
5VYK
673
6B8U
6CAD
8143417
86199_r_at
A0A2R8Y467
A0A2R8Y679
A0A2R8Y8E0
A0A2R8YDP5
A0A2R8YES9
A0A2U3TZI2
A_23_P42935
AAA35609
AAA96495
AAD15551
AAD43193
AAI01758
AAI12080
AC006344
AC006347
ACD11489
AM989472
AM989473
AM989474
AM989475
AM989476
AM989477
BC101757
BC112079
BRAF
BRAF-220
CAA46301
CAB004552
CAQ43111
CAQ43112
CAQ43113
CAQ43114
CAQ43115
CAQ43116
CCDS5863
CH236950
EAL24023
ENSG00000157764
ENSP00000493543
ENST00000646891
ENST00000646891.1
EntrezGene:673
EntrezGene:BRAF
EU600171
g4757867_3p_a_at
GE58163
GE766137
GO:0000165
GO:0000166
GO:0000186
GO:0003674
GO:0004672
GO:0004674
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005975
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007165
GO:0008150
GO:0008219
GO:0009887
GO:0010628
GO:0010828
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0033138
GO:0035556
GO:0042802
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0046872
GO:0046982
GO:0048856
GO:0055085
GO:0070374
GO:0070413
GO:0071277
GO:0090150
H7C560
H7C5K3
HGNC:1097
HPA001328
HPA071048
ILMN_1652472
IPR000719
IPR001245
IPR002219
IPR003116
IPR008271
IPR011009
IPR017441
IPR020454
IPR029071
LRG_299
M21001
M95712
M95712_at
MIM:115150
MIM:163950
MIM:164757
MIM:211980
MIM:613706
MIM:613707
NM_004333
NP_004324
PF00130
PF02196
PF07714
PH_hs_0027912
PR00008
SM00109
SM00220
SM00455
TC07001927.hg
UPI000013DF26
X65187
Participant Of
hasMember
activated RAF monomer [cytosol]
hasComponent
p-S445,T599,T602,S729 B-Raf complex [cytosol]
hasCandidate
'activator' RAFs [cytosol]
Other forms of this molecule
p-S,T-BRAF [cytosol]
BRAF-MACF1fusion [cytosol]
p-BRAF-MACF1 fusion [cytosol]
BRAF E501G [cytosol]
BRAF D594N [cytosol]
BRAF D638E [cytosol]
BRAF G596R [cytosol]
BRAF D594V [cytosol]
BRAF G596V [cytosol]
BRAF G466E [cytosol]
BRAF D594G [cytosol]
BRAF L505H [cytosol]
BRAF F595L [cytosol]
BRAF L597V [cytosol]
BRAF G464E [cytosol]
BRAF N581D [cytosol]
BRAF E586K [cytosol]
BRAF V600K [cytosol]
BRAF A246P [cytosol]
BRAF G469V [cytosol]
BRAF T244P [cytosol]
BRAF G469R [cytosol]
BRAF L597R [cytosol]
BRAF G469E [cytosol]
BRAF L597Q [cytosol]
BRAF G466A [cytosol]
BRAF G466V [cytosol]
BRAF N581S [cytosol]
BRAF G464V [cytosol]
p-BRAF L597V [plasma membrane]
p-BRAF L505H [plasma membrane]
p-BRAF G464E [plasma membrane]
p-BRAF F595L [plasma membrane]
p-BRAF A246P [plasma membrane]
p-BRAF E586K [plasma membrane]
p-BRAF N581D [plasma membrane]
p-BRAF V600K [plasma membrane]
p-BRAF G464V [plasma membrane]
p-BRAF T244P [plasma membrane]
p-BRAF G469E [plasma membrane]
p-BRAF G466V [plasma membrane]
p-BRAF G469V [plasma membrane]
p-BRAF G466A [plasma membrane]
p-BRAF L597Q [plasma membrane]
p-BRAF L597R [plasma membrane]
p-BRAF N581S [plasma membrane]
p-BRAF G469R [plasma membrane]
BRAF 599dupT [cytosol]
BRAF G534R [cytosol]
BRAF S467A [cytosol]
BRAF K601N [cytosol]
BRAF G469A [cytosol]
BRAF L485F [cytosol]
BRAF Q257R [cytosol]
BRAF K499E [cytosol]
BRAF V600E [cytosol]
BRAF K601E [cytosol]
BRAF V600E V169_M438del [cytosol]
BRAF V600E V47_D380del [cytosol]
BRAF V600E V47_M438del [cytosol]
V600E BRAF V169_D380del [cytosol]
p-S445,S729-BRAF [plasma membrane]
BRAF [cytosol]
p-S365,S445,S729 BRAF [cytosol]
hyperphosphorylated BRAF [plasma membrane]
p-S445,T599,S602,S729 BRAF [plasma membrane]
p-S445,S729-BRAF [cytosol]
Inferred To
Homologues of p-S445,T599,S602,S729 BRAF [cytosol] (Dictyostelium discoideum)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Bos taurus)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Caenorhabditis elegans)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Canis familiaris)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Danio rerio)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Dictyostelium discoideum)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Drosophila melanogaster)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Gallus gallus)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Mus musculus)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Rattus norvegicus)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Sus scrofa)
phospho-p-S445,T599,S602,S729 BRAF [cytosol] (Xenopus tropicalis)
Ghost homologue of p-S445,T599,S602,S729 BRAF [cytosol] (Saccharomyces cerevisiae)
Modified Residues
Name
O-phospho-L-serine at 445
Coordinate
445
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_004324.2
ZINC - World Drugs
BRAF_HUMAN
OpenTargets
ENSG00000157764
ZINC - FDA approved
BRAF_HUMAN
ZINC - Substances
BRAF_HUMAN
ZINC - Biogenic
BRAF_HUMAN
ZINC target
P15056
PRO
P15056
PDB
3SKC
,
1UWJ
,
4G9R
,
6U2H
,
5JRQ
,
5HI2
,
3TV4
,
2L05
,
5VAM
,
6UAN
,
5J2R
,
4R5Y
,
5VYK
,
3PSB
,
3TV6
,
5VAL
,
5VR3
,
5CSW
,
3NY5
,
4XV1
,
6B8U
,
4E26
,
5J18
,
4YHT
,
3PRF
,
5FD2
,
4G9C
,
4WO5
,
3PRI
,
4KSP
,
3C4C
,
4MBJ
,
1UWH
,
4MNF
,
4E4X
,
4FK3
,
6N0P
,
4FC0
,
6NSQ
,
6U2G
,
4JVG
,
5ITA
,
4KSQ
,
3IDP
,
3D4Q
,
3II5
,
5J17
,
5C9C
,
4DBN
,
4XV3
,
4RZW
,
4XV2
,
4RZV
,
3PSD
,
4CQE
,
3Q4C
,
5CSX
,
5CT7
,
4EHE
,
3PPJ
,
5JSM
,
4XV9
,
4EHG
,
3PPK
,
3OG7
,
5HIE
,
6CAD
,
3Q96
,
4H58
,
4PP7
,
4MNE
,
5HID
,
5JT2
,
2FB8
ZINC - Investigational
BRAF_HUMAN
ZINC - Metabolites
BRAF_HUMAN
GeneCards
P15056
ZINC - Predictions - Purchasable
BRAF_HUMAN
Orphanet
15376
HMDB Protein
HMDBP02597
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q02750 MAP2K1
7
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
p-S,218, S222,T292 MAP2K1 [cytosol]
(R-HSA-5674490)
p-T286,T292-MAP2K1 [cytosol]
(R-HSA-112374)
p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-HSA-112339)
MAP2K1 [cytosol]
(R-HSA-59502)
p-S218,S222-MAP2K1 [cytosol]
(R-HSA-109837)
0.976
58
UniProt:P04049 RAF1
10
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.957
55
UniProt:P15056 BRAF
68
BRAF-MACF1fusion [cytosol]
(R-HSA-6802402)
p-S,T-BRAF [cytosol]
(R-HSA-169856)
p-BRAF-MACF1 fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
BRAF G469R [cytosol]
(R-HSA-9648621)
BRAF L597R [cytosol]
(R-HSA-9648617)
BRAF G469E [cytosol]
(R-HSA-9648618)
BRAF L597Q [cytosol]
(R-HSA-9648619)
BRAF G466A [cytosol]
(R-HSA-9648613)
BRAF G466V [cytosol]
(R-HSA-9648838)
BRAF N581S [cytosol]
(R-HSA-9648850)
BRAF G464V [cytosol]
(R-HSA-9648611)
p-BRAF L597V [plasma membrane]
(R-HSA-8936647)
p-BRAF L505H [plasma membrane]
(R-HSA-9648862)
p-BRAF G464E [plasma membrane]
(R-HSA-8936645)
p-BRAF F595L [plasma membrane]
(R-HSA-8936641)
p-BRAF A246P [plasma membrane]
(R-HSA-9651188)
p-BRAF E586K [plasma membrane]
(R-HSA-8936639)
p-BRAF N581D [plasma membrane]
(R-HSA-9651191)
p-BRAF V600K [plasma membrane]
(R-HSA-8936651)
p-BRAF G464V [plasma membrane]
(R-HSA-9648633)
p-BRAF T244P [plasma membrane]
(R-HSA-9651194)
p-BRAF G469E [plasma membrane]
(R-HSA-9648634)
p-BRAF G466V [plasma membrane]
(R-HSA-9648859)
p-BRAF G469V [plasma membrane]
(R-HSA-9648628)
p-BRAF G466A [plasma membrane]
(R-HSA-9648629)
p-BRAF L597Q [plasma membrane]
(R-HSA-9648630)
p-BRAF L597R [plasma membrane]
(R-HSA-9648631)
p-BRAF N581S [plasma membrane]
(R-HSA-9648866)
p-BRAF G469R [plasma membrane]
(R-HSA-9648627)
BRAF 599dupT [cytosol]
(R-HSA-6802281)
BRAF G534R [cytosol]
(R-HSA-9651134)
BRAF S467A [cytosol]
(R-HSA-9651161)
BRAF K601N [cytosol]
(R-HSA-9648857)
BRAF G469A [cytosol]
(R-HSA-6802381)
BRAF L485F [cytosol]
(R-HSA-9651147)
BRAF Q257R [cytosol]
(R-HSA-9651157)
BRAF K499E [cytosol]
(R-HSA-9651142)
BRAF V600E [cytosol]
(R-HSA-6802498)
BRAF K601E [cytosol]
(R-HSA-9648833)
BRAF V600E V169_M438del [cytosol]
(R-HSA-6802489)
BRAF V600E V47_D380del [cytosol]
(R-HSA-6802491)
BRAF V600E V47_M438del [cytosol]
(R-HSA-6802495)
V600E BRAF V169_D380del [cytosol]
(R-HSA-6802486)
p-S445,S729-BRAF [plasma membrane]
(R-HSA-8933622)
BRAF [cytosol]
(R-HSA-167224)
p-S365,S445,S729 BRAF [cytosol]
(R-HSA-5672667)
hyperphosphorylated BRAF [plasma membrane]
(R-HSA-5675199)
p-S445,T599,S602,S729 BRAF [plasma membrane]
(R-HSA-5672679)
p-S445,S729-BRAF [cytosol]
(R-HSA-5672673)
p-S445,T599,S602,S729 BRAF [cytosol]
(R-HSA-5672676)
0.907
13
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.864
8
UniProt:P01112 HRAS
17
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me-2xPalmS HRAS [plasma membrane]
(R-HSA-9647912)
0.783
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.763
5
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.758
5
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.758
5
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S576 ARAF [plasma membrane]
(R-HSA-5672648)
p-S299,S302,T452,T455,S576 ARAF [cytosol]
(R-HSA-5672646)
p-S576 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S576 ARAF [cytosol]
(R-HSA-5672639)
0.744
4
UniProt:P36507 MAP2K2
5
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 [cytosol]
(R-HSA-59504)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
0.744
7
UniProt:Q13233 MAP3K1
2
p-T1400,T1412-MAP3K1 [cytosol]
(R-HSA-2685607)
MAP3K1 [cytosol]
(R-HSA-166866)
0.609
2
UniProt:P01111 NRAS
19
NRAS [plasma membrane]
(R-HSA-62725)
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
S-Farn-Me PalmS NRAS [plasma membrane]
(R-HSA-9647910)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
0.591
3
UniProt:Q02156 PRKCE
2
PRKCE [cytosol]
(R-HSA-58202)
p-T566,T710,S729-PRKCE [plasma membrane]
(R-HSA-198260)
0.589
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
0.564
2
UniProt:P46940 IQGAP1
3
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.544
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.527
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
2
UniProt:Q61097
5
KSR1 [cytosol]
(R-MMU-5672587)
phospho-p-S311,S406 KSR1 [cytosol]
(R-MMU-5672654)
phospho-p-S311 KSR1 [cytosol]
(R-MMU-5672652)
phospho-p-S311,Y552 KSR1 [plasma membrane]
(R-MMU-5672659)
phospho-p-S311,Y552 KSR1 [cytosol]
(R-MMU-5672656)
0.499
3
UniProt:Q99N57
10
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
(R-MMU-5624465)
RAF1 [cytosol]
(R-MMU-167205)
phospho-p-S338-RAF1 [cytosol]
(R-MMU-5624469)
phospho-p-S259,S621-RAF1 [cytosol]
(R-MMU-109786)
phospho-p-S621-RAF1 [plasma membrane]
(R-MMU-206222)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(R-MMU-5675193)
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-MMU-5675420)
phospho-p-S621-RAF1 [cytosol]
(R-MMU-206028)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-MMU-5672665)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-MMU-5672664)
0.499
3
© 2020
Reactome
![p-S445,T599,S602,S729 BRAF [cytosol] icon](/icon/R-ICO-012447.svg){kind=icon}