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BRAP [cytosol]
Stable Identifier
R-HSA-5672938
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
BRAP autoubiquitinates (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
p21 RAS:GTP:BRAP [plasma membrane] (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
BRAP binds KSR1:MARK3 (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
BRAP binds RAS:GTP (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
p21 RAS:GTP:BRAP [plasma membrane] (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
BRAP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7Z569 BRAP
Gene Names
BRAP, RNF52
Chain
chain:1-592
Reference Genes
BioGPS Gene:8315 BRAP
COSMIC (genes):BRAP BRAP
CTD Gene:8315 BRAP
dbSNP Gene:8315 BRAP
ENSEMBL:ENSG00000089234 BRAP
HGNC:1099 BRAP
KEGG Gene (Homo sapiens):8315 BRAP
Monarch:8315 BRAP
NCBI Gene:8315 BRAP
OMIM:604986 BRAP
UCSC:Q7Z569 BRAP
Reference Transcript
RefSeq:NM_006768.4 BRAP
Other Identifiers
0001740195
11724633_at
11751151_a_at
16770256
209922_at
209923_s_at
213473_at
3471701
3471703
3471705
3471706
3471707
3471708
3471709
3471710
3471711
3471712
3471713
3471724
3471726
3471727
3471728
3471729
3471730
3471733
3471734
35500_at
41512_at
63075_s_at
7966427
8315
A_23_P53614
GE54285
GO:0000151
GO:0000165
GO:0003674
GO:0003676
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0007165
GO:0007265
GO:0008139
GO:0008150
GO:0008270
GO:0009968
GO:0016567
GO:0016740
GO:0031965
GO:0032991
GO:0042802
GO:0043167
GO:0043226
GO:0046872
GO:0061630
HMNXSV003015347
Hs.122764.1.S1_3p_s_at
PH_hs_0025720
TC12001974.hg
g3252871_3p_a_at
Participates
as an input of
BRAP binds KSR1:MARK3 (Homo sapiens)
BRAP binds RAS:GTP (Homo sapiens)
as a component of
p21 RAS:GTP:BRAP [plasma membrane] (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
Other forms of this molecule
ub-BRAP [cytosol]
Inferred To
ETP1 [cytosol]
(Saccharomyces cerevisiae)
brap [cytosol]
(Danio rerio)
brap-2 [cytosol]
(Caenorhabditis elegans)
Brap [cytosol]
(Mus musculus)
Brap [cytosol]
(Rattus norvegicus)
BRAP [cytosol]
(Bos taurus)
BRAP [cytosol]
(Canis familiaris)
BRAP [cytosol]
(Dictyostelium discoideum)
BRAP [cytosol]
(Gallus gallus)
BRAP [cytosol]
(Plasmodium falciparum)
BRAP [cytosol]
(Schizosaccharomyces pombe)
BRAP [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_006759.3
OpenTargets
ENSG00000089234
IntEnz
2.3.2.27
GeneCards
Q7Z569
HPA
ENSG00000089234-BRAP
Ensembl
ENSG00000089234
,
ENST00000419234
,
ENSP00000403524
PRO
Q7Z569
Pharos - Targets
Q7Z569
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z569 BRAP
2
ub-BRAP [cytosol]
(R-HSA-5674001)
BRAP [cytosol]
(R-HSA-5672938)
0.573
2
UniProt:Q9BW85 YJU2
0.556
3
UniProt:Q5JVL4 EFHC1
0.547
2
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.524
3
UniProt:O75969 AKAP3
0.508
2
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.508
3
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