p-S311,S406 KSR1:MARK3 binds YWHAB dimer

Stable Identifier
R-HSA-5672954
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MARK3-mediated phosphorylation of S311 and particularly S406 promotes the binding of 14-3-3 dimers, sequestering KSR1 in the cytosol in quiescent cells (Cacace et al, 1999; Muller et al, 2000; Muller et al, 2001; reviewed in Raabe and Raap, 2003). Mutation of S406 abrogates 14-3-3 binding and results in constitutive plasma membrane localization of KSR1 (Muller et al, 2001).

Literature References
PubMed ID Title Journal Year
10891492 Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

Muller, J, Cacace, AM, Lyons, WE, McGill, CB, Morrison, DK

Mol Cell Biol 2000
12932339 Ras signaling: PP2A puts Ksr and Raf in the right place

Raabe, T, Rapp, UR

Curr. Biol. 2003
11741534 C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

Muller, J, Ory, S, Copeland, T, Piwnica-Worms, H, Morrison, DK

Mol Cell 2001
9858547 Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

Cacace, AM, Michaud, NR, Therrien, M, Mathes, K, Copeland, T, Rubin, GM, Morrison, DK

Mol Cell Biol 1999
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created