PP2A dephosphorylates KSR1

Stable Identifier
R-HSA-5672957
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon growth factor stimulation, KSR1 is dephosphorylated at S406 by PP2A, disrupting 14-3-3 binding and promoting membrane translocation of KSR1 (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).

Literature References
PubMed ID Title Journal Year
11741534 C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

Muller, J, Ory, S, Copeland, T, Piwnica-Worms, H, Morrison, DK

Mol Cell 2001
12932339 Ras signaling: PP2A puts Ksr and Raf in the right place

Raabe, T, Rapp, UR

Curr. Biol. 2003
12932319 Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

Ory, S, Zhou, M, Conrads, TP, Veenstra, TD, Morrison, DK

Curr Biol 2003
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created