YWHAB dimer dissociates from KSR1:MARK3

Stable Identifier
R-HSA-5672958
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dephosphorylation of KSR1 S406 by PP2A promotes the dissociation of 14-3-3 from this site, exposing both the CR1 region that is required for membrane localization of KSR1 and the MAPK-binding FxFP motif (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).

Literature References
PubMed ID Title Journal Year
11741534 C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

Muller, J, Ory, S, Copeland, T, Piwnica-Worms, H, Morrison, DK

Mol Cell 2001
12932339 Ras signaling: PP2A puts Ksr and Raf in the right place

Raabe, T, Rapp, UR

Curr. Biol. 2003
12932319 Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

Ory, S, Zhou, M, Conrads, TP, Veenstra, TD, Morrison, DK

Curr Biol 2003
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created