YWHAB dimer dissociates from dephosphorylated RAF

Stable Identifier
R-HSA-5672960
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Dephosphorylation of S259 (S365/S214) by PP2A promotes the transient dissociation of 14-3-3 dimers from this site (Ory et al, 2003; Jaumot et al, 2001; Rommel et al, 1996; reviewed in Raabe and Raap, 2003; Matallanas et al, 2011). In the case of RAF1, displacement of 14-3-3 has also been shown to be promoted by a direct interaction between RAF1 and the cell cycle protein prohibitin (PHB; Rajalingam et al, 2005; reviewed in Rajalingam and Rudel, 2005; Chowdhury et al, 2014).

Literature References
PubMed ID Title Journal Year
16041367 Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration

Rajalingam, K, Wunder, C, Brinkmann, V, Churin, Y, Hekman, M, Sievers, C, Rapp, UR, Rudel, T

Nat. Cell Biol. 2005
11494123 Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

Jaumot, M, Hancock, JF

Oncogene 2001
12932339 Ras signaling: PP2A puts Ksr and Raf in the right place

Raabe, T, Rapp, UR

Curr. Biol. 2003
12932319 Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

Ory, S, Zhou, M, Conrads, TP, Veenstra, TD, Morrison, DK

Curr Biol 2003
24347342 Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway

Chowdhury, I, Thompson, WE, Thomas, K

J. Cell. Physiol. 2014
8637718 Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1

Rommel, C, Radziwill, G, Lovri?, J, Noeldeke, J, Heinicke, T, Jones, D, Aitken, A, Moelling, K

Oncogene 1996
16294014 Ras-Raf signaling needs prohibitin

Rajalingam, K, Rudel, T

Cell Cycle 2005
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
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