RAS GEFs promote RAS nucleotide exchange

Stable Identifier
R-HSA-5672965
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human genome is predicted to encode 27 RAS guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP on membrane-associated RAS in response to RAS-MAPK pathway activation by growth factors, hormones, cytokines and other stimuli (reviewed in Cherfils and Zeghouf, 2013; Cargnello and Roux, 2011). Nucleotide exchange stimulates a conformational change in RAS to facilitate its interaction with RAF, ultimately promoting the phosphorylation of downstream effectors MAPK3 and MAPK1 (also known as ERK1 and ERK2) (reviewed in Cseh et al, 2014; Vigil et al, 2010).

Literature References
PubMed ID Title Journal Year
24937142 "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway

Cseh, B, Doma, E, Baccarini, M

FEBS Lett. 2014
21372320 Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Cargnello, M, Roux, PP

Microbiol. Mol. Biol. Rev. 2011
21102635 Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Vigil, D, Cherfils, J, Rossman, KL, Der, CJ

Nat. Rev. Cancer 2010
23303910 Regulation of small GTPases by GEFs, GAPs, and GDIs

Cherfils, J, Zeghouf, M

Physiol. Rev. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Ras guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created