Reactome | RAS GEFs promote RAS nucleotide exchange

RAS GEFs promote RAS nucleotide exchange

Stable Identifier

R-HSA-5672965

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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RAS GEFs promote RAS nucleotide exchange

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The human genome is predicted to encode 27 RAS guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP on membrane-associated RAS in response to RAS-MAPK pathway activation by growth factors, hormones, cytokines and other stimuli (reviewed in Cherfils and Zeghouf, 2013; Cargnello and Roux, 2011). Nucleotide exchange stimulates a conformational change in RAS to facilitate its interaction with RAF, ultimately promoting the phosphorylation of downstream effectors MAPK3 and MAPK1 (also known as ERK1 and ERK2) (reviewed in Cseh et al, 2014; Vigil et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
21372320	Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases Roux, PP, Cargnello, M	Microbiol. Mol. Biol. Rev.	2011
24937142	"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway Baccarini, M, Cseh, B, Doma, E	FEBS Lett.	2014
21102635	Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Der, CJ, Vigil, D, Rossman, KL, Cherfils, J	Nat. Rev. Cancer	2010
23303910	Regulation of small GTPases by GEFs, GAPs, and GDIs Zeghouf, M, Cherfils, J	Physiol. Rev.	2013