Reactome: A Curated Pathway Database

RAS GEFs promote RAS nucleotide exchange

Stable Identifier
R-HSA-5672965
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The human genome is predicted to encode 27 RAS guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP on membrane-associated RAS in response to RAS-MAPK pathway activation by growth factors, hormones, cytokines and other stimuli (reviewed in Cherfils and Zeghouf, 2013; Cargnello and Roux, 2011). Nucleotide exchange stimulates a conformational change in RAS to facilitate its interaction with RAF, ultimately promoting the phosphorylation of downstream effectors MAPK3 and MAPK1 (also known as ERK1 and ERK2) (reviewed in Cseh et al, 2014; Vigil et al, 2010).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
Ras guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane] RAS GEFs [plasma membrane] Ras guanyl-nucleotide exchange factor activity (0005088)
Orthologous Events