MAP2Ks phosphorylate MAPKs

Stable Identifier
R-HSA-5672973
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (residues T202 and Y204 in MAPK3, residues T185 and Y187 in MAPK1) (Ray et al, 1988; reviewed in Roskoski, 2012b). MAPK3 and MAPK1 are 84% identical and appear to be stimulated in parallel by all known activators of the MAPK pathway (Lefloch et al, 2009; reviewed in Lloyd, 2006).

Literature References
PubMed ID Title Journal Year
16879721 Distinct functions for ERKs?

Lloyd, AC

J. Biol. 2006
3287375 Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo

Ray, LB, Sturgill, TW

Proc. Natl. Acad. Sci. U.S.A. 1988
22569528 ERK1/2 MAP kinases: structure, function, and regulation

Roskoski, R Jr

Pharmacol. Res. 2012
19242111 Total ERK1/2 activity regulates cell proliferation

Lefloch, R, Pouysségur, J, Lenormand, P

Cell Cycle 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created