Reactome | p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex

p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex

Stable Identifier

R-HSA-5673768

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, lysosomal membrane

ReviewStatus

5/5

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p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex

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When cellular energy is depleted, the active AMPK complex (bound to AMPK, AMPK alpha phosphorylated on Thr-172 or Thr-174) phosphorylates the mTORC1 component RPTOR (Raptor) on Ser-722 and Ser-792. These phosphorylations are required for inhibition of mTORC1 activity in response to energy stress (Gwinn et al. 2008), and are believed to promote the dissociation of mTORC1 from the ULK1 complex (Wong et al. 2013). This reduces mTORC1 phosphorylation of ULK1 Ser-758, which consequently is able to associate with, and be activated by, AMPK (Egan et al. 2011). This coordinated phosphorylation of ULK1 by mTORC1 and AMPK may provide a mechanism by which cells can properly respond to a wide range of stimuli.

Literature References

PubMed ID	Title	Journal	Year
18439900	AMPK phosphorylation of raptor mediates a metabolic checkpoint Mihaylova, MM, Mery, A, Shaw, RJ, Turk, BE, Vasquez, DS, Gwinn, DM, Egan, DF, Shackelford, DB	Mol Cell	2008