Reactome | ub-BRAP [cytosol]

ub-BRAP [cytosol]

Stable Identifier

R-HSA-5674001

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        BRAP autoubiquitinates (Homo sapiens)
        
        p21 RAS:GTP:ub-BRAP [plasma membrane] (Homo sapiens)
        
        ub-BRAP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z569 BRAP

Gene Names

BRAP, RNF52

Chain

chain:1-592

Reference Genes

BioGPS Gene:8315 BRAP

COSMIC (genes):BRAP BRAP

CTD Gene:8315 BRAP

dbSNP Gene:8315 BRAP

ENSEMBL:ENSG00000089234 BRAP

HGNC:1099 BRAP

KEGG:hsa:8315 BRAP

Monarch:8315 BRAP

NCBI Gene:8315 BRAP

OMIM:604986 BRAP

UCSC:Q7Z569 BRAP

Reference Transcript

RefSeq:NM_006768.4 BRAP

Other Identifiers

11724633_at

11751151_a_at

16770256

209922_PM_at

209922_at

209923_PM_s_at

209923_s_at

213473_PM_at

213473_at

3471701

3471703

3471705

3471706

3471707

3471708

3471709

3471710

3471711

3471712

3471713

3471724

3471725

3471726

3471727

3471728

3471729

3471730

3471732

3471733

3471734

35500_at

41512_PM_at

41512_at

63075_s_at

7966427

8315

A_23_P53614

GE54285

GO:0000151

GO:0000165

GO:0003676

GO:0003824

GO:0004842

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0007265

GO:0008139

GO:0008270

GO:0009968

GO:0016567

GO:0016740

GO:0031965

GO:0042802

GO:0046872

GO:0061630

GO:0140096

HMNXSV003015347

Hs.122764.1.S1_3p_s_at

PH_hs_0025720

TC12001974.hg

g3252871_3p_a_at

Participates

as a component of

p21 RAS:GTP:ub-BRAP [plasma membrane] (Homo sapiens)

Other forms of this molecule

BRAP [cytosol]

Inferred To

F1NJH4 [cytosol] (Gallus gallus)

Dmel\CG5555 [cytosol] (Drosophila melanogaster)

brap [cytosol] (Danio rerio)

brap [cytosol] (Xenopus tropicalis)

Brap [cytosol] (Rattus norvegicus)

Q95QN6 [cytosol] (Caenorhabditis elegans)

BRAP [cytosol] (Bos taurus)

BRAP [cytosol] (Canis familiaris)

BRAP [cytosol] (Sus scrofa)

Q99MP8 [cytosol] (Mus musculus)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_006759.3

ENSEMBL

ENST00000419234, ENSP00000403524

OpenTargets

ENSG00000089234

HPA

ENSG00000089234-BRAP

PRO

Q7Z569

Pharos - Targets

Q7Z569

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5JVL4 EFHC1			0.659	3
UniProt:Q7Z569 BRAP	2	ub-BRAP [cytosol] (R-HSA-5674001) BRAP [cytosol] (R-HSA-5672938)	0.573	2
UniProt:Q9BW85 YJU2	1	YJU2 [nucleoplasm] (R-HSA-9770430)	0.556	3
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	4
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.524	3
UniProt:O75969 AKAP3			0.508	2
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.508	3

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