BRAP autoubiquitinates

Stable Identifier
R-HSA-5674022
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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BRAP autoubiquitinates
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Binding to activated RAS stimulates the ubiquitinase activity of BRAP, promoting autoubiquitination and relieving the inhibition of KSR1 (Methany et al, 2004; Chen et al, 2008; Methany et al, 2009).
Literature References
PubMed ID Title Journal Year
14724641 Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

White, MA, Kortum, RL, Lewis, RE, Razidlo, GL, Matheny, SA, Chen, C

Nature 2004
18332145 IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds

White, MA, Lewis, RE, Chen, C

J. Biol. Chem. 2008
19091743 Signaling threshold regulation by the Ras effector IMP

White, MA, Matheny, SA

J. Biol. Chem. 2009
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin protein ligase activity of p21 RAS:GTP:BRAP [plasma membrane]

Physical Entity
p21 RAS:GTP:BRAP [plasma membrane] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
BRAP autoubiquitinates (Bos taurus)
BRAP autoubiquitinates (Caenorhabditis elegans)
BRAP autoubiquitinates (Canis familiaris)
BRAP autoubiquitinates (Danio rerio)
BRAP autoubiquitinates (Drosophila melanogaster)
BRAP autoubiquitinates (Gallus gallus)
BRAP autoubiquitinates (Mus musculus)
BRAP autoubiquitinates (Rattus norvegicus)
BRAP autoubiquitinates (Sus scrofa)
BRAP autoubiquitinates (Xenopus tropicalis)
Authored
Rothfels, K  (2015-02-06)
Reviewed
Roskoski, R Jr  (2015-04-29)
Created
Rothfels, K  (2015-02-10)
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