Reactome: A Curated Pathway Database

BRAP autoubiquitinates

Stable Identifier
R-HSA-5674022
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Binding to activated RAS stimulates the ubiquitinase activity of BRAP, promoting autoubiquitination and relieving the inhibition of KSR1 (Methany et al, 2004; Chen et al, 2008; Methany et al, 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin protein ligase activity of p21 RAS:GTP:BRAP [plasma membrane] p21 RAS:GTP:BRAP [plasma membrane] ubiquitin protein ligase activity (0061630)
Orthologous Events