BRAP autoubiquitinates

Stable Identifier
R-HSA-5674022
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Binding to activated RAS stimulates the ubiquitinase activity of BRAP, promoting autoubiquitination and relieving the inhibition of KSR1 (Methany et al, 2004; Chen et al, 2008; Methany et al, 2009).

Literature References
PubMed ID Title Journal Year
18332145 IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds

Chen, C, Lewis, RE, White, MA

J. Biol. Chem. 2008
14724641 Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

Matheny, SA, Chen, C, Kortum, RL, Razidlo, GL, Lewis, RE, White, MA

Nature 2004
19091743 Signaling threshold regulation by the Ras effector IMP

Matheny, SA, White, MA

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of p21 RAS:GTP:BRAP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed