WDR83:LAMTOR2:LAMTOR3 binds MAPK components

Stable Identifier
R-HSA-5674132
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

LAMTOR3 (also known as MEK partner 1, MP1) exists in an obligatory complex with LAMTOR2 (p14) at the endosomal membrane where they act as a scaffold and promote MAPK activation (Schaeffer et al, 1998; Teis et al, 2002; Teis et al, 2006; Sharma et al, 2005). The LAMTOR2/LAMTOR3 complex may also be part of a larger molecular weight complex at the endosome that includes the MAPK organizer protein MORG1 (Vomastek et al, 2004; Sharma et al, 2005; reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
15547943 MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling

Sharma, C, Vomastek, T, Tarcsafalvi, A, Catling, AD, Schaeffer, HJ, Eblen, ST, Weber, MJ

J. Cell. Biochem. 2005
12479806 Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

Teis, D, Wunderlich, W, Huber, LA

Dev. Cell 2002
17178906 p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis

Teis, D, Taub, N, Kurzbauer, R, Hilber, D, de Araujo, ME, Erlacher, M, Offterdinger, M, Villunger, A, Geley, S, Bohn, G, Klein, C, Hess, MW, Huber, LA

J. Cell Biol. 2006
9733512 MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

Schaeffer, HJ, Catling, AD, Eblen, ST, Collier, LS, Krauss, A, Weber, MJ

Science 1998
15118098 Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

Vomastek, T, Schaeffer, HJ, Tarcsafalvi, A, Smolkin, ME, Bissonette, EA, Weber, MJ

Proc. Natl. Acad. Sci. U.S.A. 2004
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created