Reactome: A Curated Pathway Database

PAQR3 binds inactive RAFs

Stable Identifier
R-HSA-5674140
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PAQR3, also known as RKTG (Raf kinase trapping to Golgi) is a multi-pass transmembrane protein that binds to RAF1 and BRAF and sequesters them in the Golgi. This inhibits the interaction of RAF with activated RAS and the plasma membrane and inhibits RAF signaling (Feng et al, 2007; Fan et al, 2008; Luo et al, 2008).

Literature References
Participants
Participant Of
Orthologous Events