MAP2Ks phosphorylate MAPK at the Golgi membrane

Stable Identifier
R-HSA-5674373
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated MAP2Ks in complex with IL17RD phosphorylate MAPKs at the Golgi membrane. IL17RD prevents the dissociation of phosphorylated MAPK from the complex at the Golgi as assessed by coimmunoprecipitation, preventing MAPK nuclear translocation and activation of nuclear targets (Torii et al, 2004; reviewed in Philips, 2004; Brown and Sacks, 2009).

Literature References
PubMed ID Title Journal Year
15260967 Sef: a MEK/ERK catcher on the Golgi

Philips, MR

Mol. Cell 2004
19091303 Protein scaffolds in MAP kinase signalling

Brown, MD, Sacks, DB

Cell. Signal. 2009
15239952 Sef is a spatial regulator for Ras/MAP kinase signaling

Torii, S, Kusakabe, M, Yamamoto, T, Maekawa, M, Nishida, E

Dev Cell 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine/tyrosine kinase activity of IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created