Negative feedback regulation of MAPK pathway

Stable Identifier
R-HSA-5674499
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

MAPK pathway activation is limited by a number of negative feedback loops established by MAPK-dependent phosphorylations. Known substrates of activated MAPK proteins that lie upstream in the RAF/MAPK pathway include SOS, RAF1, BRAF, and MAP2K1 (Buday et al, 1995; Dong et al, 1996; Dougherty et al, 2005; Sturm et al, 2010; Fritsche-Guenther et al, 2011; Rushworth et al, 2006; Brummer et al, 2003; Ritt et al, 2010; Catalanotti et al, 2009)

Literature References
PubMed ID Title Journal Year
19219045 A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal

Catalanotti, F, Reyes, G, Jesenberger, V, Galabova-Kovacs, G, de Matos Simoes, R, Carugo, O, Baccarini, M

Nat. Struct. Mol. Biol. 2009
15664191 Regulation of Raf-1 by direct feedback phosphorylation

Dougherty, MK, Müller, J, Ritt, DA, Zhou, M, Zhou, XZ, Copeland, TD, Conrads, TP, Veenstra, TD, Lu, KP, Morrison, DK

Mol. Cell 2005
16508002 Regulation and role of Raf-1/B-Raf heterodimerization

Rushworth, LK, Hindley, AD, O'Neill, E, Kolch, W

Mol. Cell. Biol. 2006
8626428 SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways

Dong Chen, D C, Waters, SB, Holt, KH, Pessin, JE

J. Biol. Chem. 1996
7478553 Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos

Buday, L, Warne, PH, Downward, J

Oncogene 1995
14654779 Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

Brummer, T, Naegele, H, Reth, M, Misawa, Y

Oncogene 2003
21177493 The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

Sturm, OE, Orton, R, Grindlay, J, Birtwistle, M, Vyshemirsky, V, Gilbert, D, Calder, M, Pitt, A, Kholodenko, B, Kolch, W

Sci Signal 2010
21613978 Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

Fritsche-Guenther, R, Witzel, F, Sieber, A, Herr, R, Schmidt, N, Braun, S, Brummer, T, Sers, C, Blüthgen, N

Mol. Syst. Biol. 2011
19933846 Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

Ritt, DA, Monson, DM, Specht, SI, Morrison, DK

Mol. Cell. Biol. 2010
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