Reactome: A Curated Pathway Database

Negative feedback regulation of MAPK pathway

Stable Identifier
R-HSA-5674499
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

MAPK pathway activation is limited by a number of negative feedback loops established by MAPK-dependent phosphorylations. Known substrates of activated MAPK proteins that lie upstream in the RAF/MAPK pathway include SOS, RAF1, BRAF, and MAP2K1 (Buday et al, 1995; Dong et al, 1996; Dougherty et al, 2005; Sturm et al, 2010; Fritsche-Guenther et al, 2011; Rushworth et al, 2006; Brummer et al, 2003; Ritt et al, 2010; Catalanotti et al, 2009)

Literature References
Participants
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Cross References