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RAC1:GDP [plasma membrane]
Stable Identifier
R-HSA-5674631
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Activation of RAC1 (Homo sapiens)
Activation of RAC1 by SOS (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Inactivation of CDC42 and RAC1 (Homo sapiens)
Inactivation of RAC1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of RAC1 downstream of NMDARs (Homo sapiens)
p-S516-ARHGEF7 activates RAC1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET promotes cell motility (Homo sapiens)
MET activates RAP1 and RAC1 (Homo sapiens)
DOCK7 activates RAC1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through CDK5 (Homo sapiens)
NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Activated NTRK2 signals through FYN (Homo sapiens)
NTRK2 activates RAC1 (Homo sapiens)
DOCK3 activates RAC1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
RAC1 GDIs block activation of RAC1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1:GDP [plasma membrane] (Homo sapiens)
Participants
components
GDP [cytosol]
RAC1 [plasma membrane]
(Homo sapiens)
Participates
as an input of
RAC1 GDIs block activation of RAC1 (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Homo sapiens)
Activation of RAC1 by SOS (Homo sapiens)
DOCK7 activates RAC1 (Homo sapiens)
NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)
DOCK3 activates RAC1 (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)
DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
p-VAV family:PIP3 binds RAC1:GDP (Homo sapiens)
p-S516-ARHGEF7 activates RAC1 (Homo sapiens)
Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
as an output of
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
Inactivation of RAC1 (Homo sapiens)
as a component of
p-VAV family:PIP3:RAC1:GDP [plasma membrane] (Homo sapiens)
Inferred To
RAC1:GDP [plasma membrane]
(Bos taurus)
RAC1:GDP [plasma membrane]
(Caenorhabditis elegans)
RAC1:GDP [plasma membrane]
(Canis familiaris)
RAC1:GDP [plasma membrane]
(Danio rerio)
RAC1:GDP [plasma membrane]
(Dictyostelium discoideum)
RAC1:GDP [plasma membrane]
(Drosophila melanogaster)
RAC1:GDP [plasma membrane]
(Gallus gallus)
RAC1:GDP [plasma membrane]
(Mus musculus)
RAC1:GDP [plasma membrane]
(Sus scrofa)
RAC1:GDP [plasma membrane]
(Xenopus tropicalis)
Rac1:GDP [plasma membrane]
(Rattus norvegicus)
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