Activated MAPKs phosphorylate BRAF

Stable Identifier
R-HSA-5675198
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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BRAF is subject to MAPK-dependent phosphorylation that limits its activity. Phosphorylation of S151 inhibits binding of BRAF to activated RAS, while phosphorylation of T401, S750 and S753 abrogates heterodimerization with RAF1 (Ritt et al, 2010; Rushworth et al, 2006; Brummer et al, 2003).

Literature References
PubMed ID Title Journal Year
14654779 Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

Brummer, T, Naegele, H, Reth, M, Misawa, Y

Oncogene 2003
16508002 Regulation and role of Raf-1/B-Raf heterodimerization

Rushworth, LK, Hindley, AD, O'Neill, E, Kolch, W

Mol. Cell. Biol. 2006
19933846 Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

Ritt, DA, Monson, DM, Specht, SI, Morrison, DK

Mol. Cell. Biol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [cytosol]
Physical Entity
Activity
Orthologous Events
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