Reactome: A Curated Pathway Database

PEA15 binds MAPK monomers and dimers

Stable Identifier
R-HSA-5675206
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PEA15 is a cytoplasmic anchor that binds directly to activated MAPKs prevents their translocation into the nucleus (Formstecher et al, 2001; Whitehurst et al, 2004; Hill et al, 2002; Chou et al, 2003). PEA15 also protects phosphorylated MAPKs in the cytoplasm from inactivating dephosphorylation (Mace et al, 2013). In this way, binding of PEA15 promotes phosphorylation of cytoplasmic MAPK targets at the expense of nuclear ones.

Literature References
Participants
Participant Of
Orthologous Events