PEA15 binds MAPK monomers and dimers

Stable Identifier
R-HSA-5675206
Type
Reaction
Species
Homo sapiens
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Summation

PEA15 is a cytoplasmic anchor that binds directly to activated MAPKs prevents their translocation into the nucleus (Formstecher et al, 2001; Whitehurst et al, 2004; Hill et al, 2002; Chou et al, 2003). PEA15 also protects phosphorylated MAPKs in the cytoplasm from inactivating dephosphorylation (Mace et al, 2013). In this way, binding of PEA15 promotes phosphorylation of cytoplasmic MAPK targets at the expense of nuclear ones.

Literature References
PubMed ID Title Journal Year
11702783 PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

Formstecher, E, Ramos, JW, Fauquet, M, Calderwood, DA, Hsieh, JC, Canton, B, Nguyen, XT, Barnier, JV, Camonis, J, Ginsberg, MH, Chneiweiss, H

Dev. Cell 2001
14506247 PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation

Chou, FL, Hill, JM, Hsieh, JC, Pouysségur, J, Brunet, A, Glading, A, Uberall, F, Ramos, JW, Werner, MH, Ginsberg, MH

J. Biol. Chem. 2003
14707138 The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions

Whitehurst, AW, Robinson, FL, Moore, MS, Cobb, MH

J. Biol. Chem. 2004
23575685 Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK

Mace, PD, Wallez, Y, Egger, MF, Dobaczewska, MK, Robinson, H, Pasquale, EB, Riedl, SJ

Nat Commun 2013
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