Nuclear DUSPs dephosphorylate MAPKs

Stable Identifier
R-HSA-5675373
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MAPKs are inactivated by dephosphorylation of the activation loop T and Y residues by dual-specificity MAPK phosphatases (DUSPs) (reviewed in Roskoski, 2012b). Class 1 DUSPs, including DUSP 1, 2, 4 and 5 are nuclear and are generally activated by the same extracellular stimuli that promote MAPK signaling, establishing a negative feedback loop. DUSP5 is specific for MAPK3 and 1, while the other class 1 enzymes have broad specificity. Nuclear MAPKs may also be inactivated by nuclear forms of class III DUSPs, including DUSP8, 10 and 16, although the preferred substrate of these enzymes are the p38 and JNK MAP kinases (reviewed in Bermudez et al, 2010; Kondoh and Nishida, 2007).

Literature References
PubMed ID Title Journal Year
20463170 The dual-specificity MAP kinase phosphatases: critical roles in development and cancer Am. J. Physiol., Cell Physiol. 2010
17208316 Regulation of MAP kinases by MAP kinase phosphatases Biochim. Biophys. Acta 2007
22569528 ERK1/2 MAP kinases: structure, function, and regulation Pharmacol. Res. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine/serine/threonine phosphatase activity of nuclear MAPK DUSPs [nucleoplasm]
Physical Entity
Activity
Orthologous Events