Cytosolic DUSPs dephosphorylate MAPKs

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R-HSA-5675376
Type
Reaction
Species
Homo sapiens
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Summation

MAPKs are inactivated by dephosphorylation of the activation loop T and Y residues by dual-specificity MAPK phosphatases (DUSPs) (reviewed in Roskoski, 2012b). Cytosolic MAPKs are dephosphorylated by the MAPK-specific class II DUSPs 6,7 and 9, but may also be dephosphorylated by cytosolic forms of class III DUSPs 8, 10 and 16, which preferentially dephosphorylate p38 and JNK MAP kinases (reviewed in Bermudez et al, 2010; Kandoh and Nishida, 2007).

Literature References
PubMed ID Title Journal Year
20463170 The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

Bermudez, O, Pagès, G, Gimond, C

Am. J. Physiol., Cell Physiol. 2010
17208316 Regulation of MAP kinases by MAP kinase phosphatases

Kondoh, K, Nishida, E

Biochim. Biophys. Acta 2007
22569528 ERK1/2 MAP kinases: structure, function, and regulation

Roskoski, R Jr

Pharmacol. Res. 2012
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Participant Of
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Catalyst Activity
Title
protein tyrosine/serine/threonine phosphatase activity of cytosolic MAPK DUSPs [cytosol]
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Activity
Orthologous Events
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Reviewed