Reactome: A Curated Pathway Database

Cytosolic DUSPs dephosphorylate MAPKs

Stable Identifier
R-HSA-5675376
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MAPKs are inactivated by dephosphorylation of the activation loop T and Y residues by dual-specificity MAPK phosphatases (DUSPs) (reviewed in Roskoski, 2012b). Cytosolic MAPKs are dephosphorylated by the MAPK-specific class II DUSPs 6,7 and 9, but may also be dephosphorylated by cytosolic forms of class III DUSPs 8, 10 and 16, which preferentially dephosphorylate p38 and JNK MAP kinases (reviewed in Bermudez et al, 2010; Kandoh and Nishida, 2007).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine/serine/threonine phosphatase activity of cytosolic MAPK DUSPs [cytosol] cytosolic MAPK DUSPs [cytosol] protein tyrosine/serine/threonine phosphatase activity (0008138)
Orthologous Events