Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
Stable Identifier
R-HSA-5675414
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PEBP1 binds activated RAF1 (Homo sapiens)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
Participants
components
'activator' RAFs [cytosol]
(Homo sapiens)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(Homo sapiens)
p21 RAS:GTP [plasma membrane]
(Homo sapiens)
YWHAB dimer [cytosol]
(Homo sapiens)
Participates
as an input of
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
PEBP1 binds activated RAF1 (Homo sapiens)
as a component of
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
Inferred To
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Bos taurus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Caenorhabditis elegans)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Canis familiaris)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Drosophila melanogaster)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Gallus gallus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Plasmodium falciparum)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Rattus norvegicus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Sus scrofa)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
(Xenopus tropicalis)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text