PP2A dephosphorylates RAF1

Stable Identifier
R-HSA-5675431
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues. PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
15664191 Regulation of Raf-1 by direct feedback phosphorylation

Dougherty, MK, Müller, J, Ritt, DA, Zhou, M, Zhou, XZ, Copeland, TD, Conrads, TP, Veenstra, TD, Lu, KP, Morrison, DK

Mol. Cell 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A [cytosol]
Physical Entity
Activity
This entity is regulated by
Orthologous Events
Authored
Reviewed