PP2A dephosphorylates RAF1

Stable Identifier
R-HSA-5675431
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues. PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
21779496 Raf family kinases: old dogs have learned new tricks Genes Cancer 2011
15664191 Regulation of Raf-1 by direct feedback phosphorylation Mol. Cell 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A [cytosol]
Physical Entity
Activity
This entity is regulated by
Orthologous Events