PP2A dephosphorylates RAF1

Stable Identifier
R-HSA-5675431
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues. PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
15664191 Regulation of Raf-1 by direct feedback phosphorylation

Dougherty, MK, M├╝ller, J, Ritt, DA, Zhou, M, Zhou, XZ, Copeland, TD, Conrads, TP, Veenstra, TD, Lu, KP, Morrison, DK

Mol. Cell 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created