Reactome | PP2A dephosphorylates RAF1

PP2A dephosphorylates RAF1

Stable Identifier

R-HSA-5675431

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues. PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
15664191	Regulation of Raf-1 by direct feedback phosphorylation Zhou, XZ, Veenstra, TD, Dougherty, MK, Lu, KP, Müller, J, Copeland, TD, Zhou, M, Morrison, DK, Conrads, TP, Ritt, DA	Mol. Cell	2005
21779496	Raf family kinases: old dogs have learned new tricks Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A	Genes Cancer	2011