PP5 dephosphorylates RAF1 S338

Stable Identifier
R-HSA-5675433
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PPP5C dephosphorylates S338 in the NtA region of RAF1, which reduces the catalytic activity of RAF1 towards MAP2K proteins (von Kriegsheim et al, 2006; reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
21779496 Raf family kinases: old dogs have learned new tricks Genes Cancer 2011
16892053 Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5 Nat. Cell Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PPP5C [cytosol]
Physical Entity
Activity
Orthologous Events