PP5 dephosphorylates RAF1 S338

Stable Identifier
R-HSA-5675433
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PPP5C dephosphorylates S338 in the NtA region of RAF1, which reduces the catalytic activity of RAF1 towards MAP2K proteins (von Kriegsheim et al, 2006; reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
16892053 Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

von Kriegsheim, A, Pitt, A, Grindlay, GJ, Kolch, W, Dhillon, AS

Nat. Cell Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PPP5C [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created