PP5 dephosphorylates RAF1 S338

Stable Identifier
R-HSA-5675433
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PP5 dephosphorylates RAF1 S338
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PPP5C dephosphorylates S338 in the NtA region of RAF1, which reduces the catalytic activity of RAF1 towards MAP2K proteins (von Kriegsheim et al, 2006; reviewed in Matallanas et al, 2011).
Literature References
PubMed ID Title Journal Year
16892053 Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

Grindlay, GJ, Dhillon, AS, Kolch, W, Pitt, A, von Kriegsheim, A

Nat. Cell Biol. 2006
21779496 Raf family kinases: old dogs have learned new tricks

Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A

Genes Cancer 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine phosphatase activity of PPP5C [cytosol]

Physical Entity
PPP5C [cytosol] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
PP5 dephosphorylates RAF1 S338 (Bos taurus)
PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)
PP5 dephosphorylates RAF1 S338 (Canis familiaris)
PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)
PP5 dephosphorylates RAF1 S338 (Mus musculus)
PP5 dephosphorylates RAF1 S338 (Plasmodium falciparum)
PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)
PP5 dephosphorylates RAF1 S338 (Sus scrofa)
PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)
Authored
Rothfels, K  (2015-02-16)
Reviewed
Roskoski, R Jr  (2015-04-29)
Created
Rothfels, K  (2015-02-16)
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