EDA:EDAR binds EDARADD

Stable Identifier
R-HSA-5675656
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ectodysplasin-A (EDA) is a trimeric type II membrane protein related to the tumor necrosis factor (TNF)-related ligand family. Activation of the NF-kappaB pathway by the tumor necrosis factor receptor superfamily member EDAR (EDAR) and its downstream adaptator EDAR-associated death domain (EDARADD) is essential for the development and regulation of hair follicles, teeth, exocrine glands and other ectodermal structures (Yan et al. 2002). EDA isoform 1 specifically binds EDAR. A small number of hypohidrotic ectodermal dysplasias (HEDs) are caused by mutations in EDARADD (Chassaing et al. 2010).

Literature References
PubMed ID Title Journal Year
11882293 Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice

Yan, M, Zhang, Z, Brady, JR, Schilbach, S, Fairbrother, WJ, Dixit, VM

Curr. Biol. 2002
20222921 Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases

Chassaing, N, Cluzeau, C, Bal, E, Guigue, P, Vincent, MC, Viot, G, Ginisty, D, Munnich, A, Smahi, A, Calvas, P

Br. J. Dermatol. 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created