Reactome | EDARADD [cytosol]

EDARADD [cytosol]

Stable Identifier

R-HSA-5675659

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ectodysplasin-A receptor-associated adapter protein, EDAD_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q6ZNA4 RNF111

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External Reference Information

External Reference

UniProt:Q8WWZ3 EDARADD

Gene Names

EDARADD

Chain

chain:1-215

Reference Genes

BioGPS Gene:128178 EDARADD

COSMIC (genes):EDARADD EDARADD

CTD Gene:128178 EDARADD

dbSNP Gene:128178 EDARADD

ENSEMBL:ENSG00000186197 EDARADD

ENSEMBL_homo_sapiens_GENE:ENSG00000186197.15 EDARADD

HGNC:14341 EDARADD

KEGG Gene (Homo sapiens):128178 EDARADD

Monarch:128178 EDARADD

NCBI Gene:128178 EDARADD

OMIM:606603 EDARADD

UCSC:Q8WWZ3 EDARADD

Reference Transcript

Other Identifiers

11728640_s_at

11733212_a_at

11741217_a_at

11741218_a_at

11741219_x_at

128178

1553430_PM_a_at

1553430_a_at

16679020

2386832

2386833

2386835

2386836

2386837

2386838

2386841

2386842

2386844

2386851

2386858

2386859

2386860

2386861

2386862

2386863

2386864

2386865

2386866

2395500

2395506

2395512

2395522

2395524

7910694

A_14_P130611

A_23_P503233

GE514624

GO:0005515

GO:0005737

GO:0005829

GO:0007165

GO:0023052

GO:0030154

HMNXSV003010997

Hs2.352224.2.S1_3p_a_at

ILMN_1719206

ILMN_1754592

ILMN_1761820

PH_hs_0028214

TC01001953.hg

Participates

as a component of

EDA:EDAR:EDARADD [plasma membrane] (Homo sapiens)

as an input of

EDA:EDAR binds EDARADD (Homo sapiens)

Inferred To

EDARADD [cytosol] (Bos taurus)

EDARADD [cytosol] (Canis familiaris)

EDARADD [cytosol] (Gallus gallus)

EDARADD [cytosol] (Sus scrofa)

Edaradd [cytosol] (Mus musculus)

Edaradd [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_665860.2, NP_542776.1

OpenTargets

ENSG00000186197

HPA

ENSG00000186197-EDARADD

GeneCards

Q8WWZ3

Ensembl

ENST00000334232, ENST00000359362, ENSP00000335076, ENSP00000352320, ENSG00000186197

PRO

Q8WWZ3

Pharos - Targets

Q8WWZ3

Orphanet

15910

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96HA8 NTAQ1			0.666	4
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	5
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.556	5
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.556	3
UniProt:G2XKQ0 SUMO5			0.556	5
UniProt:Q149N8 SHPRH	1	SHPRH [nucleoplasm] (R-HSA-5689010)	0.556	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.556	5
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.556	3

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