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TNFRSF1A [plasma membrane]
Stable Identifier
R-HSA-5675738
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tumor necrosis factor receptor superfamily member 1A, TNR1A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
LTA trimer binds TNFRSF1A,1B,14 (Homo sapiens)
LTA trimer:TNFRSF1A,1B,14 [plasma membrane] (Homo sapiens)
TNFRSF1A,1B,14 [plasma membrane] (Homo sapiens)
TNFRSF1A [plasma membrane] (Homo sapiens)
TNFRSF1A,1B,14 [plasma membrane] (Homo sapiens)
TNFRSF1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19438 TNFRSF1A
Gene Names
TNFRSF1A, TNFAR, TNFR1
Chain
signal peptide:1-29, chain:30-455, chain:41-201
Reference Genes
BioGPS Gene:7132 TNFRSF1A
COSMIC (genes):TNFRSF1A TNFRSF1A
CTD Gene:7132 TNFRSF1A
dbSNP Gene:7132 TNFRSF1A
ENSEMBL:ENSG00000067182 TNFRSF1A
HGNC:11916 TNFRSF1A
KEGG Gene (Homo sapiens):7132 TNFRSF1A
Monarch:7132 TNFRSF1A
NCBI Gene:7132 TNFRSF1A
OMIM:191190 TNFRSF1A
UCSC:P19438 TNFRSF1A
Reference Transcript
RefSeq:NM_001346092.1 TNFRSF1A
RefSeq:NM_001346091.1 TNFRSF1A
RefSeq:NM_001065.3 TNFRSF1A
Other Identifiers
0004060112
11739346_s_at
11752814_s_at
11754297_s_at
11760872_at
1563_s_at
16760329
207643_s_at
3441850
3441851
3441852
3441853
3441854
3441855
3441856
3441857
3441858
3441859
3441860
3441861
3441863
3441864
3441865
3441866
3441867
3441868
3441869
3441871
3441878
3441879
7132
7960518
A_23_P139722
GE59806
GO:0000139
GO:0002947
GO:0003176
GO:0003177
GO:0003332
GO:0003674
GO:0005031
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005739
GO:0005794
GO:0005886
GO:0005887
GO:0006464
GO:0006629
GO:0006693
GO:0006810
GO:0006915
GO:0006950
GO:0006952
GO:0006954
GO:0007165
GO:0007166
GO:0007249
GO:0008150
GO:0008219
GO:0008625
GO:0008630
GO:0009058
GO:0009986
GO:0010614
GO:0010803
GO:0016020
GO:0016021
GO:0016032
GO:0019221
GO:0022607
GO:0030154
GO:0030198
GO:0032991
GO:0033209
GO:0034641
GO:0042531
GO:0042742
GO:0043120
GO:0043123
GO:0043226
GO:0043235
GO:0044281
GO:0044403
GO:0045121
GO:0045944
GO:0048856
GO:0050728
GO:0050729
GO:0065003
GO:0071260
GO:0071550
GO:0072659
GO:1902339
GO:1903140
GO:2000304
ILMN_1685005
M58286_s_at
PH_hs_0027516
TC12001135.hg
g4507574_3p_a_at
Participant Of
hasMember
TNFRSF1A,1B,14 [plasma membrane]
Other forms of this molecule
TNFRSF1A(41-201) [extracellular region]
TNFRSF1A(22-455) [plasma membrane]
Inferred To
TNFRSF1A [plasma membrane] (Canis familiaris)
Tnfrsf1a [plasma membrane] (Mus musculus)
Tnfrsf1a [plasma membrane] (Rattus norvegicus)
TNFRSF1A(22-455) [plasma membrane] (Xenopus tropicalis)
tnfrsf1a [plasma membrane] (Danio rerio)
Cross References
RefSeq
NP_001333021.1
,
NP_001333020.1
,
NP_001056.1
OpenTargets
ENSG00000067182
ZINC - Substances
TNR1A_HUMAN
HPA
ENSG00000067182-TNFRSF1A
GeneCards
P19438
Ensembl
ENSP00000380389
,
ENSP00000162749
,
ENST00000366159
,
ENST00000162749
,
ENSG00000067182
ZINC - Biogenic
TNR1A_HUMAN
ZINC target
P19438
PRO
P19438
Orphanet
15636
ZINC - Predictions - Purchasable
TNR1A_HUMAN
PDB
1FT4
,
1ICH
,
1EXT
,
1NCF
,
1TNR
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.954
15
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.937
15
UniProt:Q13546 RIPK1
14
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K63pUb-K377-RIP1 [cytosol]
(R-HSA-5212672)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.839
6
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.773
5
UniProt:Q13490 BIRC2
5
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2 [cytosol]
(R-HSA-50847)
0.69
4
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
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