ULK1 phosphorylates ATG13 and RB1CC1

Stable Identifier
R-HSA-5675868
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ULK1 (and ULK2) can phosphorylate both ATG13 and RB1CC1 (Hosakawa et al. 2009, Jung et al. 2009). Similarly Drosophila Atg1, the orthologue of ULK1, phosphorylates Drosophila Atg13 (Chang & Neufeld 2009). This phosphorylation is believed to be activating, opposing the inactivating phosphorylation of ATG13 by mTORC1 (Kamada et al. 2000, Hosakawa et al. 2009,Chang & Neufeld 2009, Jung et al. 2009) under conditions of nutrient sufficiency.
Literature References
PubMed ID Title Journal Year
19211835 Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

Natsume, T, Yamada, N, Mizushima, N, Hosokawa, N, Guan, JL, Iemura, S, Miura, Y, Hara, T, Kishi, C, Takehana, K, Takamura, A, Kaizuka, T, Oshiro, N

Mol. Biol. Cell 2009
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!