TNFRSF6B binds TNFSF6,14,15

Stable Identifier
R-HSA-5675948
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Tumor necrosis factor ligand superfamily member 15 (TNFSF15 aka VEGI) mediates the activation of NF-kappaB and subsequently can inhibit vascular endothelial growth, angiogenesis and promote activation of caspases and apoptosis (Haridas et al. 1999). TNFSF15 can bind the secreted decoy receptor tumor necrosis factor receptor superfamily member 6B (TNFRSF6B aka DcR3). Upon binding, the cytotoxic effects of TNFSF15 are neutralised thereby protecting against apoptosis. TNFRSF6B can also neutralise the cytotoxic ligands TNFSF14 (aka LIGHT) and TNFSF6 (aka FASL) (Zhan et al. 2011).

Literature References
PubMed ID Title Journal Year
10597252 VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth

Haridas, V, Shrivastava, A, Su, J, Yu, GL, Ni, J, Liu, D, Chen, SF, Ni, Y, Ruben, SM, Gentz, R, Aggarwal, BB

Oncogene 1999
21300286 Decoy strategies: the structure of TL1A:DcR3 complex

Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U, Cheng, H, Brenowitz, M, Hui, X, Nathenson, SG, Almo, SC

Structure 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed