NIK-->noncanonical NF-kB signaling

Stable Identifier
R-HSA-5676590
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

In addition to the activation of canonical NF-kB subunits, activation of SYK pathway by Dectin-1 leads to the induction of the non-canonical NF-kB pathway, which mediates the nuclear translocation of RELB-p52 dimers through the successive activation of NF-kB-inducing kinase (NIK) and IkB kinase-alpha (IKKa) (Geijtenbeek & Gringhuis 2009, Gringhuis et al. 2009). Noncanonical activity tends to build more slowly and remain sustained several hours longer than does the activation of canonical NF-kB. The noncanonical NF-kB pathway is characterized by the post-translational processing of NFKB2 (Nuclear factor NF-kappa-B) p100 subunit to the mature p52 subunit. This subsequently leads to nuclear translocation of p52:RELB (Transcription factor RelB) complexes to induce cytokine expression of some genes (C-C motif chemokine 17 (CCL17) and CCL22) and transcriptional repression of others (IL12B) (Gringhuis et al. 2009, Geijtenbeek & Gringhuis 2009, Plato et al. 2013).

Literature References
PubMed ID Title Journal Year
21173796 Non-canonical NF-kB signaling pathway

Sun, SC

Cell Res. 2011
22017430 Non-canonical NF-?B signaling activation and regulation: principles and perspectives

Razani, B, Reichardt, AD, Cheng, G

Immunol. Rev. 2011
19302050 Regulation and function of NF-kappaB transcription factors in the immune system

Vallabhapurapu, S, Karin, M

Annu. Rev. Immunol. 2009
18322009 RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation

Vaira, S, Johnson, T, Hirbe, AC, Alhawagri, M, Anwisye, I, Sammut, B, O'Neal, J, Zou, W, Weilbaecher, KN, Faccio, R, Novack, DV

Proc. Natl. Acad. Sci. U.S.A. 2008
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