Reactome | 2xRANK binds RANKL,sRANKL trimer:RANK

2xRANK binds RANKL,sRANKL trimer:RANK

Stable Identifier

R-HSA-5676592

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The binding of RANKL trimer to RANK causes the trimerization of the receptor, which activates the signalling pathway and results in osteogenesis from progenitor cells and the activation of mature osteoclasts (Liu et al. 2010)

Literature References

PubMed ID	Title	Journal	Year
20483727	Structural and functional insights of RANKL-RANK interaction and signaling Ren, J, Wu, Y, Walter, TS, Huang, P, Stuart, DI, Liu, C, Gao, B, Zhang, S, Owens, RJ, Wedderburn, LR, Zhu, X, Tang, P	J. Immunol.	2010
9367155	A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function Anderson, DM, DuBose, RF, Tometsko, ME, Billingsley, WL, Roux, ER, Maraskovsky, E, Galibert, L, Teepe, MC, Cosman, D, Dougall, WC	Nature	1997