MRSBs reduce L-methyl-(R)-S-oxide to L-methionine

Stable Identifier
R-HSA-5676917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Methionine Sulfoxide Reductase B (MSRBs) are able to reduce methyl-(R)-S-oxide to methionine (Grimaud et al. 2001). They are specific for the reduction of protein-based methyl-(R)-S-oxide, reducing free methyl-(R)-S-oxide with very low efficiency (Lee et al. 2009). Mammals have at least 3 MSRB genes (Kryukov et al. 1999, Huang et al. 1999, Jung et al. 2002, Kim & Gladyshev 2004). They are ubiquitously expressed, no clear substrate specificities are known, all three contain a zinc atom and can use thioredoxin as an in vivo reducing agent (Kim & Gladyshev 2007).

Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
peptide-methionine (R)-S-oxide reductase activity of MSRBs [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created