MSRA reduces L-methyl-(S)-S-oxide to L-Methionine

Stable Identifier
R-HSA-5676940
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Methionine Sulfoxide Reductase A (MSRA) is a peptide-methionine-(S)-S-oxide reductase (1.8.4.11.) (Kim & Gladyshev 2007, Sreekumar et al. 2011) that can reduce both free and protein-based methionine-(S)-S-oxide (Brot et al. 1981, Boschi-Muller et al. 2008). It has been implicated in processes ranging from protection of cells against oxidative damage to the maintenance of cellular homeostasis, prevention of disease and extension of longevity (Kim & Gladyshev 2007, Brennan & Kantorow 2009). MRSA has little or no target specificity and is therefore likely to act on surface-exposed methionine sulphoxide residues of many proteins (Weissbach et al. 2002, Kantorow et al. 2012).

Literature References
PubMed ID Title Journal Year
10452521 Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA)

Kuschel, L, Hansel, A, Schönherr, R, Weissbach, H, Brot, N, Hoshi, T, Heinemann, SH

FEBS Lett. 1999
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
peptide-methionine (S)-S-oxide reductase activity of MSRA [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created