Reactome | AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex

AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex

Stable Identifier

R-HSA-5678313

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex

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AMBRA1 (activating molecule in Beclin 1-related autophagy 1) is a mammalian scaffold protein that interacts with BECN1 (Beclin-1) in the Beclin-1 complex, which consists of BECN1, PIK3C3 (VPS34), PIK3R4 (VPS15) and ATG14. AMBRA1 promotes the interaction of BECN1 with PIK3C3 (Fimia et al. 2007). AMBRA1 can simultaneously bind dynein and the Beclin-1 complex. This anchors Beclin-1 complexes to the cytoplasmic microtubule network (Di Bartolomeo et al. 2010, Fimia et al. 2011). Downregulation of AMBRA1 increased staurosporine- or etoposide-induced apoptosis (Gu et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
20921139	The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy Pagliarini, V, D'Amelio, M, Romagnoli, A, Matteoni, S, Piacentini, M, Nardacci, R, Di Bartolomeo, S, Cecconi, F, Giunta, L, Fimia, GM, Lisi, G, Nazio, F, Corazzari, M, Antonioli, M, Oliverio, S, Fuoco, C	J Cell Biol	2010