ABCB4 transports PC from plasma membrane to extracellular region

Stable Identifier
R-HSA-5678706
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Multidrug resistance protein 3 (ATP-binding cassette sub-family B member 4, ABCB4 aka MDR3) mediates the ATP-dependent export of organic anions and drugs from hepatocytes into the canalicular lumen in the presence of bile salts. ABCB4 is especially important for the export of phospholipids such as phosphatidylcholine (PC) from the plasma membrane of hepatocytes (Morita et al. 2007). Biliary phospholipids associate with bile salts and cholesterol in mixed micelles, thereby reducing the detergent activity and cytotoxicity of bile salts and preventing cholesterol crystallisation. Thus, ABCB4 plays a crucial role in bile formation and lipid homeostasis (Morita & Terada 2014).

Literature References
PubMed ID Title Journal Year
25133187 Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts

Morita, SY, Terada, T

Biomed Res Int 2014
17523162 Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4

Morita, SY, Kobayashi, A, Takanezawa, Y, Kioka, N, Handa, T, Arai, H, Matsuo, M, Ueda, K

Hepatology 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipid transporter activity of ABCB4 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created