Reactome | ABCC2 R768W [plasma membrane]

ABCC2 R768W [plasma membrane]

Stable Identifier

R-HSA-5679033

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Multidrug resistance-associated protein 2, MRP2_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92887 ABCC2

Gene Names

ABCC2, CMOAT, CMOAT1, CMRP, MRP2

Chain

chain:1-1545

Reference Genes

BioGPS Gene:1244 ABCC2

COSMIC (genes):ABCC2 ABCC2

CTD Gene:1244 ABCC2

dbSNP Gene:1244 ABCC2

ENSEMBL:ENSG00000023839 ABCC2

HGNC:53 ABCC2

KEGG Gene (Homo sapiens):1244 ABCC2

Monarch:1244 ABCC2

NCBI Gene:1244 ABCC2

OMIM:601107 ABCC2

UCSC:Q92887 ABCC2

Reference Transcript

RefSeq:NM_000392.4 ABCC2

Other Identifiers

0003710605

11730409_at

11759031_at

1244

16708192

206155_at

3260448

3260449

3260451

3260452

3260453

3260454

3260456

3260458

3260459

3260461

3260462

3260463

3260464

3260465

3260466

3260467

3260468

3260469

3260472

3260474

3260475

3260476

3260477

3260478

3260480

3260481

3260483

3260484

3260485

3260486

3260487

3260489

3260490

3260492

3260493

3260496

3260497

3260498

3260499

3260500

33721_at

67977_at

7929779

A_14_P113705

A_23_P158976

A_23_P44569

GE62639

GO:0000003

GO:0000166

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005886

GO:0005887

GO:0006790

GO:0006810

GO:0006855

GO:0006950

GO:0006954

GO:0006979

GO:0007165

GO:0007565

GO:0008150

GO:0008514

GO:0008559

GO:0009056

GO:0009408

GO:0009986

GO:0010468

GO:0010629

GO:0015127

GO:0015694

GO:0015711

GO:0015721

GO:0015722

GO:0015723

GO:0015732

GO:0016020

GO:0016021

GO:0016324

GO:0016887

GO:0016999

GO:0019748

GO:0019904

GO:0022857

GO:0030644

GO:0031427

GO:0031526

GO:0032355

GO:0032496

GO:0033762

GO:0034641

GO:0035690

GO:0038183

GO:0042178

GO:0042493

GO:0042592

GO:0042626

GO:0042910

GO:0043167

GO:0043627

GO:0044281

GO:0046581

GO:0046618

GO:0046685

GO:0048545

GO:0050787

GO:0055085

GO:0070327

GO:0070633

GO:0071222

GO:0071347

GO:0071354

GO:0071356

GO:0071549

GO:0071716

GO:0097327

GO:0120188

GO:0150104

GO:1901086

GO:1904486

GO:1990961

GO:1990962

ILMN_1676278

ILMN_1780706

PH_hs_0011436

TC10000715.hg

U49248_at

g4557480_3p_s_at

Participant Of

hasMember

ABCC2 mutants [plasma membrane]

Other forms of this molecule

ABCC2 R1066* [plasma membrane]

ABCC2 R1150H [plasma membrane]

ABCC2 I1173F [plasma membrane]

ABCC2 [plasma membrane]

Modified Residues

Name

L-arginine 768 replaced with L-tryptophan

Coordinate

768

PsiMod

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

L-tryptophan residue [MOD:00027]

A protein modification that effectively converts a source amino acid residue to L-tryptophan.

Disease

Name	Identifier	Synonyms
Dubin-Johnson syndrome	12308	chronic idiopathic jaundice, Dubin Johnson syndrome

Cross References

RefSeq

NP_000383.1

ZINC - World Drugs

MRP2_HUMAN

OpenTargets

ENSG00000023839

ZINC - FDA approved

MRP2_HUMAN

ZINC - Substances

MRP2_HUMAN

ZINC target

Q92887

PRO

Q92887

IntEnz

7.6.2.2

HPA

ENSG00000023839-ABCC2

GeneCards

Q92887

Ensembl

ENST00000647814, ENSP00000497274, ENSG00000023839

Orphanet

15054

ZINC - Predictions - Purchasable

MRP2_HUMAN

HMDB Protein

HMDBP01658

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.508	3