Reactome: A Curated Pathway Database

MRN bound to shortened telomeres activates ATM

Stable Identifier
R-HSA-5682026
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MRN bound to shortened telomeres promotes dissociation of ATM dimers to ATM monomers which is accompanied by ATM autophosphorylation on serine residue S1981. Dissociation of ATM dimers requires the ATP-dependent DNA-helicase activity of the MRN subunit RAD50 (Lee and Paull 2005, Wu et al. 2007).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events