MRN bound to shortened telomeres activates ATM

Stable Identifier
R-HSA-5682026
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MRN bound to shortened telomeres promotes dissociation of ATM dimers to ATM monomers which is accompanied by ATM autophosphorylation on serine residue S1981. Dissociation of ATM dimers requires the ATP-dependent DNA-helicase activity of the MRN subunit RAD50 (Lee and Paull 2005, Wu et al. 2007).

Literature References
PubMed ID Title Journal Year
17694070 MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

Wu, Y, Xiao, S, Zhu, XD

Nat. Struct. Mol. Biol. 2007
15790808 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Lee, JH, Paull, TT

Science 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed