There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

LGI2 binds ADAM22,23

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Leucine-rich glioma inactivated 2 (LGI2) like LIG1, is neuronally secreted and acts on ADAM (a-disintegrin-and-metalloproteinase) family of neuronal membrane proteins, which function in synapse remodelling. Based on the experiments performed in canine and rat brain it proves that LGI2 interacts with ADAM22 and ADAM23 following secretion. Truncation of Lgi2 prevents its secretion and ADAM interactions causing remitting focal-onset epilepsy in dogs between ages one and four months, which is equivalent to human two to eight years. It has been suggested that LGI2 participates in protecting the brain against seizures during the pruning phase of neurodevelopment (Seppala et al. 2011).

Literature References
PubMed ID Title Journal Year
21829378 LGI2 truncation causes a remitting focal epilepsy in dogs PLoS Genet. 2011
Participant Of
Orthologous Events